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Therefore, there is an urgent need to design a hydrogel dressing with a \u2018lever\u2019 function to balance ROS levels in the wound to achieve both antimicrobial and anti\u2010inflammatory effects on DFUs. In this study, we synthesised ROS\u2010responsive diselenide liposomes loaded with a pro\u2010skin healing factor (ergothioneine (ET)), thrombin, and a sonosensitizer (HMME) and constructed nanocomposite \u2018lever\u2019 hydrogels modulated by ultrasound (US). During early infection, sonodynamic therapy (SDT) under US generates bactericidal ROS, cleaving diselenide bonds to release ET and thrombin. Upon US cessation, thrombin\/fibrinogen forms an in situ gel, while ET scavenges residual ROS and promotes M2 macrophage polarization in later stages. In addition, the potential immunomodulatory mechanisms of the nanocomposite \u2018lever\u2019 hydrogels were investigated via RNA sequencing. In conclusion, the novel nanocomposite \u2018lever\u2019 hydrogels effectively achieved a balance between ROS production and annihilation during different stages of wound repair while providing antibacterial and anti\u2010inflammatory properties to promote neovascularisation and improve diabetic peripheral neuropathy. In conclusion, by precisely controlling ROS levels across wound\u2010healing phases, this strategy offers a promising solution for refractory DFUs.<\/jats:p>","DOI":"10.1002\/advs.202500720","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:41:45Z","timestamp":1748335305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Ultrasound\u2010Triggered Nanocomposite \u201cLever\u201d Hydrogels with a Full Repair System Accelerates Diabetic Foot Ulcer Repair"],"prefix":"10.1002","volume":"12","author":[{"given":"Yuting","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Ultrasound Institute of Ultrasound in Medicine and Engineering Zhongshan Hospital Fudan University  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound 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