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Herein, a novel asymmetric biological composite patch (bPVA\/SIS\n                    <jats:sup>+<\/jats:sup>\n                    \u2010NP) is developed by in situ introducing zwitterionic polyvinyl alcohol molecular brush (bPVA) hydrogel to a cationic small intestinal submucosal decellularized matrix (SIS\n                    <jats:sup>+<\/jats:sup>\n                    ) via a self\u2010induced phase separation based united strategy. Due to its high hydrogen bonding crosslinking and strong mechanical interlocking with SIS\n                    <jats:sup>+<\/jats:sup>\n                    \u2010NP layer, bPVA layer can maintain stable anti\u2010contamination and the corresponding anti\u2010adhesion properties in the contaminated environment. On the basis of preserving an original extracellular matrix skeleton, SIS\n                    <jats:sup>+<\/jats:sup>\n                    \u2010NP layer can show strong contact anti\u2010bacterial ability at the acute stage of repair together with the prolonged drug release during the healing stage of repair. Furthermore, the in situ combination of bPVA and SIS\n                    <jats:sup>+<\/jats:sup>\n                    \u2010NP layers can lead to a high and stable burst pressure tolerance. By comprehensive control of bacteria and their necrotic products, bPVA\/SIS\n                    <jats:sup>+<\/jats:sup>\n                    \u2010NP patch can achieve anti\u2010infection, anti\u2010adhesion, and pro\u2010healing properties in the infectious abdominal wall defect on rats. Therefore, the bPVA\/SIS\n                    <jats:sup>+<\/jats:sup>\n                    \u2010NP patch opens a new avenue for bio\u2010friendly construction of multifunctional biological patches to address the stringent requirements of infectious abdominal wall defect repair.\n                  <\/jats:p>","DOI":"10.1002\/advs.202500865","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T10:59:47Z","timestamp":1744023587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Polymer Brush\u2010Based Asymmetric Porous Patch with Excellent Anti\u2010Bacterial and Anti\u2010Contamination Properties Enables Infectious Abdominal Wall Defect Repair"],"prefix":"10.1002","volume":"12","author":[{"given":"Zeping","family":"Huang","sequence":"first","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery) Guangdong Institute of Gastroenterology Biomedical Innovation Center Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510655 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery) Guangdong Institute of Gastroenterology Biomedical Innovation Center Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510655 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binying","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery) Guangdong Institute of Gastroenterology Biomedical Innovation Center Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010sen University Guangzhou 510655 P. R. 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