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However, the development of a clinically demand\u2010driven adhesive, ensuring both reliable adhesion and osteogenic activity, poses a significant challenge. Herein, a structurally and functionally dual\u2010biomimetic bone adhesive is developed through the design of an organic\u2013inorganic network\u2010enhanced hydrogel, which integrates caffeic acid\u2010grafted collagen (CAC), aminated laponite (ALAP), and N\u2010hydroxysuccinimide ester\u2010terminated polyethylene glycol (tetra\u2010PEG\u2010SC). Benefiting from nanosheet\u2010induced strengthening, the mechanically reinforced adhesive can maintain integrity under extreme compression (98%) and tensile (600%) deformations, facilitating anatomical repositioning of rabbit radius and porcine femur fractures. Of greater importance, the adhesive accelerated fracture healing, potentially via ROS scavenging and immunomodulation, as evidenced by reduced oxidative stress and M2 macrophage polarization in vitro. Assessed through an innovative rabbit radius comminuted fracture model, the injectable bone adhesive demonstrates rapid and flexible adhesion of bone fragments in a blood\u2010rich environment, as observed over the 2 fold improvement in biomechanical and radiological performance compared with commercially available cyanoacrylate adhesives. This intricately designed bone adhesive holds promise as a novel solution for addressing complex fracture cases in surgical treatment.<\/jats:p>","DOI":"10.1002\/advs.202501108","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T03:11:01Z","timestamp":1751944261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dual\u2010Biomimetic Bone Adhesive with Osteoimmunomodulatory Capabilities for Anatomical Reconstruction of Comminuted Fractures"],"prefix":"10.1002","volume":"12","author":[{"given":"Junyao","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing 100853 China"},{"name":"Chinese PLA Medical School  Beijing 100853 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hufei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General 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