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Here an engineered probiotic powered micro\u2010rod robot for targeted and penetrative treatment for thrombus is developed. This micro\u2010rod robot (\n                    <jats:sub>Sr<\/jats:sub>\n                    EcN\n                    <jats:sub>PL<\/jats:sub>\n                    ) using natural probiotics as bio\u2010carriers, functionalized with thrombolytic carbon nanotubes and platelet membrane\u2010coated nanoparticles loaded with targeted vasodilators. The robot exploits the rapid movement of probiotics, combined with the active targeting ability of the platelet membrane, to achieve rapid and precise drug delivery to thrombus tissue. Based on the natural rod\u2010shaped structure of probiotics,\n                    <jats:sub>Sr<\/jats:sub>\n                    EcN\n                    <jats:sub>PL<\/jats:sub>\n                    can deeply penetrate thrombus tissue, achieving faster thrombolysis efficiency. The thrombolytic micro\u2010robot combines thrombus\u2010targeting capability with prolonged circulation time and controlled vasodilation, maintaining vascular patency and inhibiting secondary thrombus. Results indicate that this micro\u2010robot can quickly and accurately target and penetrate thrombus tissue, extending the biological half\u2010life of thrombolytic drugs by \u2248332 times and enabling sustained thrombolysis. This novel dual\u2010pronged combined thrombolytic therapy has significant scientific implications for treating thrombotic diseases with narrow therapeutic windows caused by vascular injury.\n                  <\/jats:p>","DOI":"10.1002\/advs.202501304","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T18:41:13Z","timestamp":1756406473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Engineered Probiotic\u2010Powered Micro\u2010Rod Robot Bomb for Thrombus\u2010Penetrating Explosion"],"prefix":"10.1002","volume":"12","author":[{"given":"Riyue","family":"Liu","sequence":"first","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases  Xiamen 361006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases  Xiamen 361006 China"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, School of Rehabilitation Medicine Wenzhou Medical University  Wenzhou Zhejiang 325035 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases  Xiamen 361006 China"},{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, School of Rehabilitation Medicine Wenzhou Medical University  Wenzhou Zhejiang 325035 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Nawsherwan","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases  Xiamen 361006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuilian","family":"Dai","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases  Xiamen 361006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases  Xiamen 361006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases  Xiamen 361006 China"},{"name":"Hebei Key Laboratory of Cardiac Injury Repair Mechanism Study The First Hospital of Hebei Medical University  Shijiazhuang 050031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kecheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, School of Rehabilitation Medicine Wenzhou Medical University  Wenzhou Zhejiang 325035 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-0892","authenticated-orcid":false,"given":"Mangmang","family":"Sang","sequence":"additional","affiliation":[{"name":"Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases  Xiamen 361006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306841"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13575"},{"key":"e_1_2_8_4_1","first-page":"326","volume":"135","author":"Abbattista M.","year":"2020","journal-title":"J. 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