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However, challenges such as limited induction of immune responses and systemic immune toxicity have hindered its clinical applications. Here, a zeolite imidazolate framework\u20108 (ZIF\u20108) that encapsulates mitoxantrone (MIT), an immune cell death (ICD)\u2010inducing chemotherapeutic agent (MIT@ZIF\u20108), is synthesized using a one\u2010pot aqueous\u2010phase process. ZIF\u20108 serves as a dual\u2010functional nanomaterial for chemo\u2010immunotherapy: a carrier to enhance tumor uptake of MIT for improved chemotherapy efficacy, and a pyroptosis inducer to amplify MIT\u2010induced ICD for augmented anti\u2010tumor immune responses. As a result, in vivo administration of MIT@ZIF\u20108 markedly inhibits tumor growth in both immunologically \u201chot\u201d colon cancer and immunologically \u201ccold\u201d prostate cancer. Moreover, MIT@ZIF\u20108 treatment increases the abundance of cytotoxic CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and reduces the amount of immunosuppressive regulatory T cells in tumors, thereby enhancing anti\u2010tumor immunity and sensitizing prostate cancer to anti\u2010CTLA\u20104 immunotherapy. In summary, MIT@ZIF\u20108 offers a highly translational approach for chemo\u2010immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202501542","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T09:10:17Z","timestamp":1739524217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mitoxantrone\u2010Encapsulated ZIF\u20108 Enhances Chemo\u2010Immunotherapy via Amplified Immunogenic Cell Death"],"prefix":"10.1002","volume":"12","author":[{"given":"Junhong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology Fudan University Shanghai Cancer Center  Shanghai 200032 P. R. China"},{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai 200032 P. R. 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