{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:13:15Z","timestamp":1788585195229,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20309"],"award-info":[{"award-number":["U22A20309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301533"],"award-info":[{"award-number":["82301533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Impulsivity is a core pathological feature of various psychiatric disorders including obsessive\u2010compulsive disorder, attention\u2010deficit\/hyperactivity disorder, and schizophrenia, which is conceptualized as dysregulated motivational and inhibitory processes. However, the underlying neural mechanism is poorly known.\u00a0Using an olfactory cued Go\/No\u2010Go task, this work finds increased false alarm rate, shortened licking onset latency, elevated licking frequency and reduced inter\u2010trial consistency in mice treated by the NMDAR antagonist (MK\u2010801).\u00a0Fiber optic recordings reveal MK\u2010801 enhanced cue\u2010evoked neuronal responses in the olfactory bulb (OB), orbitofrontal cortex (OFC), ventral tegmental area (VTA), and nucleus accumbens (NAc), while reducing reward\u2010predictive cue selectivity and increasing NAc dopamine release. Additionally, in vivo electrophysiological recordings demonstrate that theta oscillation power in the NAc and its coherence with OB, OFC, and VTA are also amplified. MK\u2010801 treatment enhances the correlation between firing rates of NAc neurons and cue, decreases the association with reward, strengthens the correlation with licking and increases the probability of firing peak preceding lick onset. Furthermore, this work confirms that the application of the trace amine\u2010associated receptor 1 agonist SEP\u2010363856 could correct the abnormal responses of NAc neurons and behavioral deficits. These findings elucidate the neural basis of impulsivity and support the\u00a0potential therapeutic effect of\u00a0SEP.<\/jats:p>","DOI":"10.1002\/advs.202502079","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:14:13Z","timestamp":1761308053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cortico\u2010Striatal\u2010Midbrain Circuit Dysregulation Underlying MK\u2010801 Induced Impulsivity and the Ameliorative Effects of SEP"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-9870","authenticated-orcid":false,"given":"Xueru","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Hearing Research, School of Life Sciences China Medical University Shenyang Liaoning 110122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyu","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Hearing Research, School of Life Sciences China Medical University Shenyang Liaoning 110122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Physiology China Medical University Shenyang Liaoning 110122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology China Medical University Shenyang Liaoning 110122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Laboratory of Hearing Research, School of Life Sciences China Medical University Shenyang Liaoning 110122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-7947","authenticated-orcid":false,"given":"Pingting","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology The First Hospital of China Medical University Shenyang 110001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-3833","authenticated-orcid":false,"given":"Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"Laboratory of Hearing Research, School of Life Sciences China Medical University Shenyang Liaoning 110122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.11.1783"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9438-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(02)00104-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-05918-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.08.022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3280ba4989"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00218-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.04.052"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-022-03870-x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.6.1041"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(03)00077-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bsl.787"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00013"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa397"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.05.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09159"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02194-w"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0477-20.2020"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14739"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.07.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx180"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290090001001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.09.020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00019-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1995.03950240079013"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2021.10.003"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.260281"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413185"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-019-00757-6"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.57"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.10.003"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1598-11.2011"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24572"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852913000722"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-1111-0"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.11.011"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.579349"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2956"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.4.1659"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00235545"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094341"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10754"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2019.05.005"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0194-19.2019"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6491-10.2011"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2024.114895"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12518"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108382"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10060947"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.08.018"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2018.05.003"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5007-13.2014"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2022.04.007"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43400"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34955"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2018.1480723"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0740-6"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.06.007"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.11.003"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.1.13"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.113"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015906776359540"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2017.1323870"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13121641"},{"key":"e_1_2_9_66_1","volume-title":"Drugs and Lactation Database (LactMed\u00ae)","author":"\u201cXanomeline\u201d","year":"2006"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.06.020"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202502079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202502079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202502079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T08:49:38Z","timestamp":1773650978000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202502079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/advs.202502079"],"URL":"https:\/\/doi.org\/10.1002\/advs.202502079","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"assertion":[{"value":"2025-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02079"}}