{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:04:08Z","timestamp":1793343848266,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370430 82130012 81830010 82400563 82200448 82201981"],"award-info":[{"award-number":["82370430 82130012 81830010 82400563 82200448 82201981"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21S11903000 23ZR1458800 20YF1444200 23YF1432800"],"award-info":[{"award-number":["21S11903000 23ZR1458800 20YF1444200 23YF1432800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Aortic dissection (AD) is a life\u2010threatening medical emergency characterized by adverse vascular remodeling. Coiled\u2010coil domain\u2010containing protein 80 (CCDC80) plays an essential role in regulating cardiovascular remodeling. This study aims to define the role of CCDC80 in the formation and development of AD. Significant downregulation of CCDC80 in vascular smooth muscle cell (VSMC) in human and mouse AD is identified. Then, CCDC80 knockout mice (CCDC80\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) and VSMC\u2010specific CCDC80 knockout mice (CCDC80\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    SM22\u03b1 Cre\n                    <jats:sup>+<\/jats:sup>\n                    ) treated with angiotensin II (Ang II) or Ang II combined with \u03b2\u2010aminopropionitrile monofumarate (BAPN) frequently develop AD with higher frequency and severity, accompanied by severe elastin fragmentation and collagen deposition. Mechanistically,\u00a0CCDC80 interacts with JAK2, and CCDC80 deficiency promotes VSMC phenotype switching, proliferation, and migration as well as matrix metalloproteinase production by activating the JAK2\/STAT3 signaling pathway. Moreover, the JAK2\/STAT3 pathway\u2010specific inhibitor ameliorates adverse vascular remodeling and reduces AD formation in CCDC80\u2010knockout mice by mitigating VSMC phenotype switching. In conclusion,\u00a0CCDC80 deficiency exacerbates the progression of events leading to AD by activating the JAK2\/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs. These findings highlight that CCDC80 is a potential key target for the prevention and treatment of AD.\n                  <\/jats:p>","DOI":"10.1002\/advs.202502108","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:35:23Z","timestamp":1745577323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype"],"prefix":"10.1002","volume":"12","author":[{"given":"Qingqing","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"},{"name":"Department of Cardiology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200080 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Peking Union Medical College Hospital Peking Union Medical College &amp; Chinese Academy of Medical Sciences  Beijing 100730 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Shanghai\u00a0Chest\u00a0Hospital Shanghai\u00a0Jiaotong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwen","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohua","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences University of Chinese Academy of Sciences  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Hocher","sequence":"additional","affiliation":[{"name":"Fifth Department of Medicine (Nephrology\/Endocrinology\/Rheumatology\/Pneumology) University Medical Centre Mannheim University of Heidelberg  69123 Heidelberg Germany"},{"name":"Reproductive and Genetic Hospital of CITIC\u2010Xiangya, People's Republic of China  Changsha 410028 China"},{"name":"IMD Institut fur Medizinische Diagnostik Berlin\u2010Potsdam GbR  14473 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4396-200X","authenticated-orcid":false,"given":"Linghong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.53"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.08.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20054094"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61005-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306361"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-013-0290-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.05.066"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314670"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.063332"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad534"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.06.004"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104164"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.456244"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.11.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00142"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21603-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056546"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001513"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.7.897"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.08.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315146"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316489"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250095"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119076"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176334"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.06.007"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11122002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3400\/avd.oa.17-00086"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-1275"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.053980"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055727"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou046"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1242"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M809535200"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412593200"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.08.025"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142315"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310692"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa352"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311450"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056640"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab109"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176009"},{"key":"e_1_2_9_45_1","first-page":"1208","volume":"145","author":"Katsuda S.","year":"1994","journal-title":"Am. J. Pathol."},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117619"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113690"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.1.12"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.03.072"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.02.020"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2018.06.194"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.08.014"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312449"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102650499"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.10.010"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001898"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122558"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308895"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000238"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202502108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202502108","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202502108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T16:22:48Z","timestamp":1775751768000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202502108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":59,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/advs.202502108"],"URL":"https:\/\/doi.org\/10.1002\/advs.202502108","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"2025-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2502108"}}