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Herein, a copper peroxide (CuO\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010coated AuCu bimetallic aerogel is developed that exhibits quadruple enzyme\u2010mimicking activity and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \/O\n                    <jats:sub>2<\/jats:sub>\n                    self\u2010supplying to modulate the complex microenvironment of\n                    <jats:italic>methicillin\u2010resistant staphylococcus aureus (MRSA)<\/jats:italic>\n                    \u2010infected diabetic wounds. The AuCu@CuO\n                    <jats:sub>2<\/jats:sub>\n                    aerogels demonstrate favorable photothermal properties and mimic four enzyme\u2010like activities: peroxidase\u2010like activity for producing toxic reactive oxygen species; catalase\u2010like activity for decomposing H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    to release O\n                    <jats:sub>2<\/jats:sub>\n                    to relieve oxidative stress and hypoxia; glucose oxidase\u2010like activity for reducing excessive blood glucose and glutathione peroxidase\u2010like activity for balancing abnormal glutathione level. The CuO\n                    <jats:sub>2<\/jats:sub>\n                    coating facilitates a continuous and adequate in situ production of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    within the mildly acidic infection microenvironment, enabling excellent antibacterial activity and reduced blood glucose levels during the initial treatment of infected diabetic wounds. Furthermore, the engineered AuCu@CuO\n                    <jats:sub>2<\/jats:sub>\n                    aerogels not only scavenge elevated ROS during the inflammatory phase but also synergistically generate oxygen to promote wound healing. Overall, the AuCu@CuO\n                    <jats:sub>2<\/jats:sub>\n                    aerogelsmicroenvironment can be activated by the diabetic wound infection microenvironments, alleviating inflammation, reducing hypoxia, lowering blood glucose levels, and enhancing angiogenesis and collagen fiber accumulation, thereby significantly improving diabetic wound healing.\n                  <\/jats:p>","DOI":"10.1002\/advs.202502391","type":"journal-article","created":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:16:11Z","timestamp":1745763371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["AuCu@CuO\n                    <sub>2<\/sub>\n                    Aerogels with H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    \/O\n                    <sub>2<\/sub>\n                    Self\u2010Supplying and Quadruple Enzyme\u2010Like Activity for\n                    <i>MRSA<\/i>\n                    \u2010Infected Diabetic Wound Management"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaofeng","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Hunan Provincial Maternal and Child Health Care Hospital &amp; NHC Key Laboratory of Birth Defect Research and Prevention &amp; MOE Key Lab of Rare Pediatric Disease Hengyang Medical School University of South China  Hengyang Hunan 421001 China"},{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital &amp; Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China  Hengyang Hunan 421001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanyun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital &amp; Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China  Hengyang Hunan 421001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital &amp; Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China  Hengyang Hunan 421001 China"},{"name":"Pathology Research Group &amp; Department of Pathology Institute of Basic Disease Sciences &amp; School of Basic Medical Sciences Xiangnan University  Chenzhou Hunan 423000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital &amp; Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China  Hengyang Hunan 421001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital &amp; Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China  Hengyang Hunan 421001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital &amp; Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China  Hengyang Hunan 421001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital &amp; Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China  Hengyang Hunan 421001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajun","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital &amp; Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China  Hengyang Hunan 421001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital &amp; Center for Molecular Imaging Probe Cancer Research Institute Hengyang Medical School University of South China  Hengyang Hunan 421001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Provincial Maternal and Child Health Care 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