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However, the role of\n                    <jats:italic>Parabacteroides johnsonii<\/jats:italic>\n                    in metabolic disorders is never reported. Here, this study finds that the abundance of\n                    <jats:italic>P. johnsonii<\/jats:italic>\n                    in the feces is negatively correlated with the blood glucose and lipid levels of obese patients. Oral administration of live\n                    <jats:italic>P. johnsonii<\/jats:italic>\n                    improved the metabolic dysfunction in high fat diet (HFD)\u2010fed mice, accompanied by the alleviation of leaky gut and the systemic inflammation.\n                    <jats:italic>P. johnsonii<\/jats:italic>\n                    enhanced the catabolism of branched\u2010chain amino acids (BCAAs) to branched\u2010chain short\u2010chain fatty acids (BSCFAs) in gut. Particularly, the conversion of valine to isobutyrate is correlated to the symptoms of obese patients. Isobutyrate intervention mirrored the favorable effects of\n                    <jats:italic>P. johnsonii<\/jats:italic>\n                    on HFD\u2010fed mice. Isobutyrate increased H3K14 acetylation at\n                    <jats:italic>Fgf1b<\/jats:italic>\n                    promoters and activated its transcription through inhibition of HDAC3 in colon, thereby maintaining the intestinal barrier integrity. The natural product stachyose exerted anti\u2010obesity effects by enhancing the growth of\n                    <jats:italic>P. johnsonii<\/jats:italic>\n                    . These\u00a0results offered insights into the mechanisms underlying the potential of\n                    <jats:italic>P. johnsonii<\/jats:italic>\n                    , isobutyrate, and stachyose in treating metabolic disorders.\n                  <\/jats:p>","DOI":"10.1002\/advs.202502624","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T09:50:42Z","timestamp":1754560242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Probiotic\n                    <i>Parabacteroides johnsonii<\/i>\n                    Ameliorates Metabolic Disorders Through Promoting BCAAs to BSCFAs Conversion"],"prefix":"10.1002","volume":"12","author":[{"given":"Yimeng","family":"Chen","sequence":"first","affiliation":[{"name":"Pukou Hospital of Chinese Medicine affiliated to China Pharmaceutical University China Pharmaceutical University  639 Longmian road Nanjing China"},{"name":"State Key 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