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This study introduces a novel, self\u2010propelled nanomedicine delivery system that forms nanoparticles within the bladder lumen by co\u2010infusing dopamine hydrochloride, Mn\n                    <jats:sup>2+<\/jats:sup>\n                    , cGAMP, and urease into the bladder to initiate in situ polymerization. The resulting Mn\u2010cGAMP@PDA\u2010urease (DMCU) nanoparticles possess a urease\u2010modified surface, which acts as an engine to generate propulsive force by breaking down urea. Consequently, this process enhances nanoparticle retention in the bladder mucosa and facilitates efficient drug delivery. The self\u2010assembled nanoparticles activate the STING pathway, promoting dendritic cell maturation and activation of T cells, thereby enhancing anti\u2010tumor immune responses. These nanoparticles remain in the bladder for an extended period, significantly improving therapeutic efficacy by sustaining drug release and reducing adverse side effects. In vivo, experiments using a mouse orthotopic model of bladder cancer demonstrate that the DMCU system enhances tumor suppression and immune activation compared with conventional therapies. This novel approach integrates nanotechnology with immunomodulation to address chemotherapy resistance and improve therapeutic efficacy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202502750","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T03:27:14Z","timestamp":1743218834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Self\u2010Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3171-3137","authenticated-orcid":false,"given":"Lei","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Urology Lanzhou University Second Hospital  Lanzhou 730000 P. R. China"},{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen 518116 P. R. 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