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Cancer cells, as key drivers of tumor metastasis, are crucial targets, but current methods for visualizing their response to theranostics are slow. Here, nondestructive real\u2010time impedance spectroscopy to monitor cancer cell response, identifying an optimal light exposure time of 60 min and defined cell viability and resistibility through impedance measurements, achieving high correlation (92.45% and 99.82%) with standard methods is used, and it is demonstrated that mild phototherapy significantly enhance chemotherapy, especially with Lenvatinib in liver cancer cell treatments. Through an in\u2010depth study, the \u201cmore light\u2010aiding, less bonding (LALB) mechanism,\u201d meaning less conjugated chemical bonding within the excitation threshold, results in more pronounced light\u2010aiding properties, is proposed. This photochemical interaction mechanism confirms that combining phototherapy and chemotherapy offers significant benefits with higher targeting and lower toxic side effects in cancer and disease treatments, providing a new strategy of photochemical interaction and coupling for drug screening and mild phototherapy integrated chemotherapy (mild\u2010PIC) treatment evaluation, and further promotes the development of other advanced biomedical applications.<\/jats:p>","DOI":"10.1002\/advs.202502836","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T02:56:31Z","timestamp":1756522591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cell Viability, Drug Screening, and Mechanism Study Under Mild Phototherapy Integrated Chemotherapy (PIC)"],"prefix":"10.1002","volume":"12","author":[{"given":"Tongge","family":"Li","sequence":"first","affiliation":[{"name":"School of Electrical and Information Engineering Jiangsu University  Zhenjiang 212000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering Jiangsu University  Zhenjiang 212000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Medicine Stanford University School of Medicine  Stanford CA 94305 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medicine Stanford University School of Medicine  Stanford CA 94305 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering Jiangsu University  Zhenjiang 212000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanglei","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Bioengineering Chongqing University  Chongqing 400030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering Jiangsu University  Zhenjiang 212000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[{"name":"Fluid Machinery Center Jiangsu University  Zhenjiang 212000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering Jiangsu University  Zhenjiang 212000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering Jiangsu University  Zhenjiang 212000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Agricultural Engineering Jiangsu University  Zhenjiang 212013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhexuan","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering Jiangsu University  Zhenjiang 212000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Electrical and Information Engineering Jiangsu University  Zhenjiang 212000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Jia","sequence":"additional","affiliation":[{"name":"State\u2010Key Laboratory of Analog and Mixed\u2010Signal VLSI Institute of Microelectronics Faculty of Science and Technology\u2010ECE University of Macau  Macau 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Innovative Design City University of Macau  Macau 999078 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavonda","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Stanford University  Stanford CA 94305 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-1095","authenticated-orcid":false,"given":"Xingcai","family":"Zhang","sequence":"additional","affiliation":[{"name":"John A. 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