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Hydrogen molecule (H\n                    <jats:sub>2<\/jats:sub>\n                    ) is proved as an emerging anti\u2010inflammatory and anti\u2010IRI agent with high biological safety, while local warm heating is well identified and able to improve tissue microcirculation for promoting wound repair. This work proposes a new strategy of visible\u2010photocatalytic hydrogen\/warm heat production for combination treatment of PU, and develops palladium nanodots\u2010deposited hydrogen\u2010doped titanium dioxide nanorod (HTON\u2010Pd) as a novel multifunctional photocatalyst, achieving controllable and sustainable visible\u2010photocatalytic production of H\n                    <jats:sub>2<\/jats:sub>\n                    and heat. Daily administration of the HTON\u2010Pd encapsulated hydrogel dressing (HTON\u2010Pd@Gel) with the assistance of visible light irradiation receives a high outcome of PU treatment. The stubborn PU wound has completely been cured after 11\u2010day treatment with HTON\u2010Pd@Gel. Mechanistically, hydrogen and warm heat photocatalytically produced by HTON\u2010Pd improve the PU wound microenvironment by synergistically promoting the proliferation and migration of skin cells, inhibiting their apoptosis, reducing the inflammatory response, and boosting the generation of new blood vessels in support of PU wound healing.\n                  <\/jats:p>","DOI":"10.1002\/advs.202503185","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T03:41:49Z","timestamp":1749526909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Local Visible\u2010Photocatalytic Production of Hydrogen and Warm Heat for Combination Treatment of Pressure Ulcer"],"prefix":"10.1002","volume":"12","author":[{"given":"Jiawei","family":"Zhu","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine School of Medicine Yangzhou University  Yangzhou 225001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering Shenzhen University Medical School  Shenzhen 518060 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Laser and Aesthetic Medicine Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Chongqing Medical University  Chongqing 401122 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200011 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuobin","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine School of Medicine Yangzhou University  Yangzhou 225001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-8838","authenticated-orcid":false,"given":"Qianjun","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Hydrogen Science &amp; Center of Hydrogen Science School of Materials Science and Engineering Shanghai Jiao Tong University  Shanghai 200240 P. R. China"},{"name":"Shenzhen Research Institute Shanghai Jiao Tong University  Shenzhen 518057 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03790-8"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.0079"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2018.0905"},{"key":"e_1_2_8_4_1","first-page":"55","volume":"57","author":"Jiang L.","year":"2011","journal-title":"Ostomy Wound Manag."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413445112"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2000.9.1.25939"},{"key":"e_1_2_8_7_1","first-page":"90","volume":"31","author":"Haesler E.","year":"2023","journal-title":"Wound Pract. 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