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Although promising, the lack of appropriate structural design strategy and limitation of sensing performance in the clinical samples remain challenging for the practical application of nanozymes. Herein, a novel copper silicate nanozyme (CSHSs\u2010Ar) with enhanced peroxidase\u2010like catalytic activity is synthesized through a facile in situ valence\u2010engineered approach. After the optimization of synthesis, the resultant CSHSs\u2010Ar nanozymes containing nearly 60% of Cu\n                    <jats:sup>+<\/jats:sup>\n                    hold a higher peroxidase\u2010like catalytic activity and a better catalytic specificity than the other two derivatives (CSHSs and CSHSs\u2010air). Theoretical calculations also demonstrate that CSHSs\u2010Ar nanozymes are more beneficial toward the activation of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    compared with CSHSs and CSHSs\u2010air. On this basis, the well\u2010developed CSHSs\u2010Ar nanozyme\u2010involved system is employed as an efficient colorimetric sensor for the detection of volatile sulfur compounds (VSCs) and prediction for periodontitis. Moreover, several visual molecular logic gates are explored as a proof of concept to the application of CSHSs\u2010Ar nanozymes with superior peroxidase\u2010like catalytic activity. This study not only provides guidance for the development of novel nanozymes, but also broadens the biomedical application potential of nanozymes including the detection of oral diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.202503237","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T08:13:59Z","timestamp":1749111239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["In Situ Valence Engineering of Copper Silicate Nanozymes with Enhanced Peroxidase\u2010Like Catalytic Activity for Oral Disease Detection"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaocan","family":"Liu","sequence":"first","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University  Changchun 130021 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Stomatology Jilin University  Changchun 130021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufu","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University  Changchun 130021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University  Changchun 130021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Dai","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University  Changchun 130021 China"},{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfu","family":"Bao","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University  Changchun 130021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology Jilin University  Changchun 130021 China"},{"name":"Key Laboratory of Pathobiology Ministry of Education Jilin University  Changchun 130021 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-6457","authenticated-orcid":false,"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin 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