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Despite treatments, 30%\u201350% of individuals show limited improvement, and neurophysiological mechanisms of treatment responsiveness remain unclear, requiring the development of objective biomarkers. In this study, multimodal electrophysiological parameters are monitored: heart rate variability (high frequency (HF), low frequency (LF), LF\/HF ratio), EEG beta and alpha relative power, and brain\u2010to\u2010heart connectivity in participants with real\u2010life state anxiety. Participants underwent a therapeutic intervention combining virtual\u2010reality immersion, hypnotic script, and a breath control exercise. Real\u2010life state anxiety is captured using the State\u2010Trait Anxiety Inventory Form Y1 (STAI\u2010Y1) scale before and after the intervention. Reduced anxiety is observed immediately after the intervention in 16 out of 27 participants. While all participants, independently of their STAI\u2010Y1 score, showed increased heart rate variability (HRV) low frequency power, only treatment\u2010responders displayed increased overall autonomic tone (high and low frequency HRV), increased midline beta power and brain\u2010to\u2010heart connectivity. Notably, the LF\/HF ratio showed a significant linear relationship with anxiety reduction, with higher ratios linked to greater therapeutic response. These findings suggest that increased cognitive regulation of brain\u2010to\u2010heart connectivity can serve as a biomarker for therapeutic efficacy, with elevated midline beta power facilitating improved cardiac tone in responders.<\/jats:p>","DOI":"10.1002\/advs.202503606","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T13:21:07Z","timestamp":1754918467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enhanced Brain\u2010Heart Connectivity as a Precursor of Reduced State Anxiety after Therapeutic Virtual Reality Immersion"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7314-8266","authenticated-orcid":false,"given":"Idil","family":"Sezer","sequence":"first","affiliation":[{"name":"Paris Brain Institute, FrontLAB, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital CNRS INSERM  Paris U1127 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