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To overcome these limitations, a radical\u2010engineered 2D black phosphorus (2D BP) nanoplatform is reported through atomic\u2010scale conjugation of aminoferrocene, creating a stable complex with enhanced electron spin resonance, named FcP. The covalent coupling strategy establishes persistent T\n                    <jats:sub>2<\/jats:sub>\n                    \u2010weighted contrast capability. Subsequent hyaluronic acid (HA) functionalization endows the HA\u2010FcP system with CD44\u2010specific targeting, achieving 1.7\u2010fold higher plaque accumulation than non\u2010targeted counterparts in apolipoprotein E\u2010deficient models. Remarkably, this nanostructure enables continuous MRI visualization of atherosclerotic lesions for 120\u00a0h post\u2010injection. Systematic biosafety evaluation demonstrates &gt;90% cell viability and normal hematological parameters. 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