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In this study, the design of a Cu\n                    <jats:sub>7<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    multifunctional nanozyme, activated by near\u2010infrared (NIR) light is presented, that demonstrates enhanced antibacterial activity. Cu\n                    <jats:sub>7<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    is synthesized with varying defect structures by utilizing different templates, which substantially optimize its absorption to H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and lipopolysaccharides (LPS) molecules. This process generates an optimal electronic structure, producing efficient antibacterial activity through photodynamic and photothermal synergetic processes. Specifically, the Cu\n                    <jats:sub>7<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    nanozyme with dual defects (\n                    <jats:italic>VCu<\/jats:italic>\n                    and\n                    <jats:italic>VCuCuCuSSS<\/jats:italic>\n                    ) exhibits peroxidase\u2010like (POD), catalase\u2010like (CAT), and GSH\u2010depletion properties, effectively inactivating drug\u2010resistant bacteria such as Pseudomonas aeruginosa. Notably, in a mouse wound model infected with\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , the nanozyme demonstrates significant antibacterial efficacy, promoting wound healing under NIR light. This multifunctional Cu\n                    <jats:sub>7<\/jats:sub>\n                    S\n                    <jats:sub>4<\/jats:sub>\n                    nanozyme presents a promising new strategy for combating drug\u2010resistant bacterial infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.202503793","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T07:29:02Z","timestamp":1749454142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cu\n                    <sub>7<\/sub>\n                    S\n                    <sub>4<\/sub>\n                    Nanozyme Efficiently Inactivating Drug\u2010Resistant Bacteria on Mouse Wound Models through Photodynamic and Photothermal Synergetic Therapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Xueya","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Life Nankai University  Tianjin 300350 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology Department of Neurology Department of Gynecology and Obstetrics Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Urology Department of Neurology Department of Gynecology and Obstetrics Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology College of Life Nankai University  Tianjin 300350 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Obstetrics Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbing","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Urology Department of Neurology Department of Gynecology and Obstetrics Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Urology Department of Neurology Department of Gynecology and Obstetrics Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghong","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Liaocheng University  Liaocheng 252000 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