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In this study, spatial transcriptional assays (NanoString CosMx) are utilized to analyze both explant and autopsy samples from non\u2010COVID and COVID\u201019 lungs, identifying the activation of proinflammatory macrophages in COVID\u201019 explants. It is further developed immuno\u2010lung organoids comprising hPSC\u2010derived alveolar and airway organoids co\u2010cultured with macrophages to investigate the impact and underlying mechanisms of macrophage\u2010mediated lung damage following SARS\u2010CoV\u20102 infection. The findings demonstrate that proinflammatory macrophages induce lung cell senescence through the THBS1\u2013(ITGA3+ITGB1) signaling axis, a mechanism further validated using spatial transcriptomics. 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