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However, it remains unknown whether and how high humidity impacts psoriasis relapse. Using unique mouse models of psoriasis relapse, we found that high humidity exposure exacerbated psoriasis recurrence by increasing skin\u2010resident memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T (T\n                    <jats:sub>RM<\/jats:sub>\n                    ) cells through a mechanism depending on its upregulation of IL\u201015R\u03b1 on keratinocytes. Keratinocyte\u2010specific knockout of IL\u201015R\u03b1 or administrating soluble sIL\u201015R\u03b1 to block IL\u201015 abrogated these effects. Moreover, the effects of high humidity on psoriasis relapse, IL\u201015R\u03b1 expression and skin T\n                    <jats:sub>RM<\/jats:sub>\n                    cell formation were attributed to cutaneous\n                    <jats:italic>Staphylococcus nepalensis<\/jats:italic>\n                    since its recolonization or its specific metabolite, asymmetric dimethylarginine (ADMA), upregulated IL\u201015R\u03b1 expression on keratinocytes, increased skin CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    cells and worsened psoriasis relapse. However, treatment with mupirocin, an antibiotic, alleviated recurrent psoriasis. In vitro experiments showed that culture supernatant of\n                    <jats:italic>Staphylococcus nepalensis<\/jats:italic>\n                    upregulated IL\u201015R\u03b1 expression on keratinocytes, while IL\u201015R\u03b1\u2010expressing keratinocytes promoted formation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    phenotypes. Finally, high humidity also aggravated psoriatic skin lesions in humanized mice. Thus, our findings enhanced a new understanding of how climatic factors govern psoriasis recurrence and unveiled a role for IL\u201015R\u03b1\u2010expressing keratinocytes in skin CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    formation and psoriasis relapse.\n                  <\/jats:p>","DOI":"10.1002\/advs.202504061","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T19:39:39Z","timestamp":1776368379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue\u2010Resident Memory T Cells via Altering Skin Microbiota"],"prefix":"10.1002","volume":"13","author":[{"given":"Chun\u2010Ling","family":"Liang","sequence":"first","affiliation":[{"name":"Section of Immunology Guangdong Provincial Academy of Chinese Medical 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