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Current therapeies for recovery remain inadequate, undersing the urgent need for innovative interventions.\u00a0In this study, a novel therapeutic approach is introduced that delivers extracellular vesicles (EVs) derived from human\u2010induced pluripotent stem cell\u2010derived neural progenitor cells (hiPSC\u2010NPCs) with a gelatin\u2010based injectable bioorthogonal hydrogel (BIOGEL). The hiPSC\u2010NPCs are conditioned with deferoxamine (DFO) to simulate hypoxia, resulting in EVs enriched with neurotrophic and angiogenic factors critical for neural repair. The biomimetic mechanical properties of BIOGEL, similar to those of native brain tissue, contribute to sustained EV delivery and promote neural regeneration. BIOGEL with hypoxia\u2010conditioned EVs showed significant tissue regeneration in vivo using a rat model of TBI. 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The synergistic combination of hypoxia\u2010conditioned EVs and biomaterial delivery offers a promising strategy for advancing regenerative medicine techniques for neural repair.<\/jats:p>","DOI":"10.1002\/advs.202504147","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T11:22:11Z","timestamp":1757330531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Advanced Biomaterial Delivery of Hypoxia\u2010Conditioned Extracellular Vesicles (EVs) as a Therapeutic Platform for Traumatic Brain Injury"],"prefix":"10.1002","volume":"12","author":[{"given":"Joshua B.","family":"Stein","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Biology Rutgers The State University of New Jersey  Piscataway NJ 08854 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songzi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of 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