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In this study, we found that\n                    <jats:italic>Fn<\/jats:italic>\n                    predominantly accumulated within colorectal cancer cells, correlating with colorectal cancer liver metastasis. Clinically, the administration of high doses of antibiotics and chemotherapeutic agents can disrupt the balance of the host microbiota. To address this clinical challenge, metronidazole (MTI) and oxaliplatin (OXA) are encapsulated within poly (lactic\u2010co\u2010glycolic acid) (PLGA) nanoparticles. Neutrophil membrane vesicles are extracted from murine bone marrow and coated with these nanoparticles (NM@PLGA\u2010MTI\u2010OXA), creating neutrophil\u2010mimetic nanoparticles with dual targeting capabilities for antibacterial and anticancer purposes. The neutrophil membrane coating, compared with free drugs, is found to enhance nanoparticle uptake by tumor cells, facilitating intracellular bacterial elimination and tumor cell death. Further experiments reveal that NM@PLGA\u2010MTI\u2010OXA reverses the\n                    <jats:italic>Fn<\/jats:italic>\n                    \u2010induced epithelial\u2010mesenchymal transition (EMT) in tumor cells during metastasis and remodels the immunosuppressive microenvironment, suppressing colorectal cancer and liver metastasis development while minimizing broad\u2010spectrum damage to the commensal microbiota.\n                  <\/jats:p>","DOI":"10.1002\/advs.202504188","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T07:17:24Z","timestamp":1748416644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Neutrophil\u2010Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"Yanan","family":"Niu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Oncology National Cancer Center\/Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College  Beijing 100021 P. 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