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Although extracellular traps (ETs) are promising therapeutic targets for recalcitrant chronic inflammation, for example, otitis media with effusion (OME), practical and specific targeting of NETs\/EETs in pathological tissues remains challenging. In this study, an ultrathin, 2D sheet\u2010like nanoscavenger C\u2010TA\n                    <jats:sub>H<\/jats:sub>\n                    is developed by modifying copper indium thiophosphate (CIPS) nanosheets with tannic acid (TA) and histone aptamers. The findings reveal that C\u2010TA\n                    <jats:sub>H<\/jats:sub>\n                    effectively binds the dsDNA of NETs\/EETs, inhibits bacterial growth, and reduces reactive oxygen species (ROS) levels, leading to a depressed local inflammation in ovalbumin (OVA)\u2010induced OME rats. In addition, the therapeutic results also include reductions in inflammatory cytokines release, suppression of ETs\u2010activated danger signaling pathways, including toll\u2010like receptor 9 (TLR9) and nuclear factor\u2010kappa B (NF\u2010\u03baB), as well as decreased mucous exudation and improved hearing functions. Comprehensively, transcriptomic analysis with RNA\u2010sequencing confirms that C\u2010TA\n                    <jats:sub>H<\/jats:sub>\n                    treatment significantly reverses the pathological gene expression changes after OVA sensitization. This work introduces an aptamer modification strategy for the target and capture of NETs\/EETs, providing a potential therapeutic approach for modulating inflammatory signaling in OME as well as other recalcitrant inflammatory disorders.\n                  <\/jats:p>","DOI":"10.1002\/advs.202504210","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T11:45:56Z","timestamp":1752493556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Targeting Neutrophil\/Eosinophil Extracellular Traps by Aptamer\u2010Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders"],"prefix":"10.1002","volume":"12","author":[{"given":"Yongqiang","family":"Xiao","sequence":"first","affiliation":[{"name":"ENT Institute Department of Facial Plastic and Reconstructive Surgery Eye &amp; ENT Hospital Fudan University  Shanghai 200031 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Wang","sequence":"additional","affiliation":[{"name":"ENT Institute Department of Facial Plastic and Reconstructive Surgery Eye &amp; 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