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Disruptions in intestinal microbiota exacerbate this imbalance; however, the mechanisms by which commensal bacteria regulate SAP\u2010induced SIRS and\/or CARS remain unclear. This study reports that the abundance of the gut commensal\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    is significantly reduced in fecal samples from patients with acute pancreatitis (AP) and is inversely associated with the severity of systemic inflammatory responses. Using Foxp3\u2010DTR and IL\u201010\u2010KO mice, it is found that\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    and its derived protein Amuc_1409 can suppress SAP\u2010induced pancreatic and systemic inflammation by increasing peripheral regulatory T cells (Tregs) and enhancing the IL\u201010 expression. Mechanistically, Amuc_1409 interacts with Ube2k to reduce the ubiquitination degradation of Foxp3, and it promotes the differentiation of Tregs and the production of IL\u201010, effectively alleviating inflammation induced by SAP. These findings highlight\n                    <jats:italic>A. muciniphila<\/jats:italic>\n                    and its derivative Amuc_1409 as promising probiotic and biomolecule for managing acute pancreatitis and potentially other inflammatory conditions.\n                  <\/jats:p>","DOI":"10.1002\/advs.202504214","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:08:22Z","timestamp":1749726502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<i>Akkermansia Muciniphila<\/i>\n                    Alleviates Severe Acute Pancreatitis via Amuc1409\u2010Ube2k\u2010Foxp3 Axis in Regulatory T Cells"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5406-4195","authenticated-orcid":false,"given":"Jinyan","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou 310016 P. 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