{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:00:51Z","timestamp":1788303651164,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072056"],"award-info":[{"award-number":["82072056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302140"],"award-info":[{"award-number":["82302140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51937010"],"award-info":[{"award-number":["51937010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271987"],"award-info":[{"award-number":["82271987"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271939"],"award-info":[{"award-number":["82271939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011882"],"award-info":[{"award-number":["2021A1515011882"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The cGAS\u2010STING signaling pathway has emerged as a promising target for cancer immunotherapy. However, STING agonists have a dual\u2010edged nature. Although they enhance antitumor T cell activity, STING agonists also elicit protumorigenic effects by promoting IL\u201035\u2010producing B regulatory (Breg) cells, suppressing natural killer (NK) cell density, and fostering immune suppression.\u00a0To address these challenges, this work develops a tumor microenvironment\u2010responsive hollow mesoporous nanosystem that degrades under high glutathione conditions, thereby releasing the STING agonist MSA\u20102 and Mn ions. This nanosystem facilitates magnetic resonance imaging\u2010guided chemodynamic therapy and radiosensitization, efficiently activating the cGAS\u2010STING pathway by disrupting mitochondrial and nuclear DNA. Notably, by integrating this nanosystem with an anti\u2010IL\u201035 blockade, this work successfully mitigates the Breg cell\u2010mediated suppression of NK cells, restores innate immune responses, and enhances antitumor efficacy. This study highlights the pivotal role of anti\u2010IL\u201035 in reversing immunosuppression, enhancing innate immunity, and establishing a synergistic theranostic platform for molecular imaging\u2010guided cancer radioimmunotherapy.<\/jats:p>","DOI":"10.1002\/advs.202504252","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T07:48:31Z","timestamp":1750924111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nanosensitizer for Cancer Radioimmunotherapy via Anti\u2010IL\u201035 Blockade Boosted Innate Immunity Activation"],"prefix":"10.1002","volume":"12","author":[{"given":"Yinfei","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Center Nanfang Hospital Southern Medical University  Guangzhou 510515 China"},{"name":"Cancer Research Institute School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Center Nanfang Hospital Southern Medical University  Guangzhou 510515 China"},{"name":"Cancer Research Institute School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushu","family":"Liao","sequence":"additional","affiliation":[{"name":"Cancer Research Institute School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zede","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Center Nanfang Hospital Southern Medical University  Guangzhou 510515 China"},{"name":"Cancer Research Institute School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Center Nanfang Hospital Southern Medical University  Guangzhou 510515 China"},{"name":"Cancer Research Institute School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Research Institute School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Affiliated Hospital of Guangzhou Medical University  Guangzhou 510260 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyu","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Center Nanfang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Center Nanfang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-5719","authenticated-orcid":false,"given":"Bingxia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cancer Research Institute School of Basic Medical Sciences Southern Medical University  Guangzhou 510515 China"},{"name":"Experimental Education\/Administration Center School of Basic Medical Science Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Center Nanfang Hospital Southern Medical University  Guangzhou 510515 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.012"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01247-w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.05.013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0761"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3558"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104037"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01250-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0346-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01801-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110588"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.03.047"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0108-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202307241"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.033"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05254-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00619-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00952-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mog2.49"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.017"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-23-0242"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12939"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00732-1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2023.05.008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201704623"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c12942"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122321"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121871"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.01.033"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207593"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b04299"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM00296E"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121415"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b18676"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24232-3"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.036"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-00965-7"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206370"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202109726"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0151-1"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01224-3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0244-x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.09.002"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14763"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02354-2"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0426-7"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.029"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.09.039"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07861"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208277"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202504252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202504252","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202504252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:12:39Z","timestamp":1785438759000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202504252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":50,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/advs.202504252"],"URL":"https:\/\/doi.org\/10.1002\/advs.202504252","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]},"assertion":[{"value":"2025-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04252"}}