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However, the postoperative outcome of CI is significantly influenced by the number of surviving SGNs, \u200b\u200bwhich is a key focus of preoperative evaluation\u200b\u200b. Existing audiologic function and radiographic tests cannot directly demonstrate the integrity of inner ear primary neurons. In this study, \u200b\u200bwe developed and validated\u200b\u200b a radionuclide\u2010labeled anti\u2010vesicular glutamate transporter 1 (anti\u2010VGLUT1) antibody\u2010drug and achieved animal\u2010level in vivo imaging of cochlear SGNs using nuclear imaging. By screening the public single\u2010cell sequencing database, it is found that VGLUT1 can serve as a representative cell membrane marker for SGN in the cochlea. The potential of anti\u2010VGLUT1 conjugated to the long half\u2010life\n                    <jats:sup>177<\/jats:sup>\n                    Lu as a molecular\u00a0probe to detect the relative number of SGNs in SGN\u2010injured mouse and pig models is explored. The study provides a novel method for assessing cochlear nerve integrity in vivo by visualizing target antigen expression levels through nuclear imaging. This approach is promising to help CI candidates with preoperative inner ear SGN integrity assessment, contributing to clinical decision\u2010making.\n                  <\/jats:p>","DOI":"10.1002\/advs.202504464","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:22:36Z","timestamp":1747642956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel\n                    <sup>177<\/sup>\n                    Lu Nuclear Molecule Label"],"prefix":"10.1002","volume":"12","author":[{"given":"Chenyang","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 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