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Cranial bone transport (CBT) technique is a safe, less invasive, and relatively simple surgical technique in bone reconstruction, which has been used to repair cranial bone defects and deformity corrections. The current studies are to determine the effects of CBT surgery on cranial bone regeneration as well as neurological functional recovery in TBI. CBT treatment alleviated lesion size and promoted learning, motor, and memory recovery in TBI rats. The meningeal lymphatic drainage function is enhanced, evidenced by increased intake of ovalbumin conjugated with Alexa Flour 647(OVA\u2010A647) in meningeal lymphatic vessels (MLVs) and deep cervical lymph nodes (dCLNs). CBT accelerated P\u2010tau clearance while decreasing Iba1 induced neuroinflammatory response in TBI rats. Notably, improvement of CBT treatment is significantly abolished by the ablation of MLVs via MAZ51, a small\u2010molecule inhibitor primarily targeting vascular endothelial growth factor receptor\u20103 (VEGFR\u20103). Furthermore, after bone transport treatment, bone regeneration in the CBT sites continued consolidation, bone defects in TBI are replaced with new bone more quickly after CBT surgery. Taken together, the study is a proof\u2010of\u2010concept de\u2010novo study to prove CBT can significantly improve the outcomes of brain recovery and cranioplasty in TBI rats.<\/jats:p>","DOI":"10.1002\/advs.202504467","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T08:35:04Z","timestamp":1748680504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats"],"prefix":"10.1002","volume":"12","author":[{"given":"Shanshan","family":"Bai","sequence":"first","affiliation":[{"name":"Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Prince of Wales Hospital  Shatin Hong Kong SAR 999077 P. R. 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