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Increasing evidence suggests that gut microbiota dysregulation can impact the initiation and progression of cancers, including colorectal cancer, breast cancer, and pancreatic cancer. This study observes that the beneficial gut bacterium\n                    <jats:italic>Parabacteroides distasonis<\/jats:italic>\n                    (\n                    <jats:italic>P. distasonis<\/jats:italic>\n                    ) is significantly decreased in bladder cancer patients, and its low abundance is strongly associated with poor prognosis.\n                    <jats:italic>P. distasonis<\/jats:italic>\n                    is a next\u2010generation probiotic which plays a vital role in human health. Furthermore, this work finds that\n                    <jats:italic>P. distasonis<\/jats:italic>\n                    culture medium inhibits metastasis and proliferation of bladder cancer cells in vitro and in vivo. This work identifies that indole\u20103\u2010acetic acid (3\u2010IAA) produced by\n                    <jats:italic>P. distasonis<\/jats:italic>\n                    exerting similar tumor\u2010suppressive effects. Mechanistically, 3\u2010IAA activates the aryl hydrocarbon receptor (AhR), which in turn downregulates fatty acid synthase (FASN) transcription in bladder cancer cells. Notably, the reduction of FASN expression decreases the ratio of MUFAs to PUFAs, thereby increasing ferroptosis sensitivity in bladder cancer cells. Collectively, this study demonstrates that\n                    <jats:italic>P. distasonis<\/jats:italic>\n                    \u2010derived 3\u2010IAA can inhibit bladder cancer metastasis and proliferation, highlighting the AhR\u2010FASN axis as a promising therapeutic target to inhibit bladder cancer progression.\n                  <\/jats:p>","DOI":"10.1002\/advs.202504688","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T06:35:54Z","timestamp":1750833354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gut\n                    <i>Parabacteroides distasonis<\/i>\n                    \u2010derived Indole\u20103\u2010Acetic Acid Promotes Phospholipid Remodeling and Enhances Ferroptosis Sensitivity via the AhR\u2010FASN Axis in Bladder Cancer"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9665-8206","authenticated-orcid":false,"given":"Weijia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510515 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentai","family":"Shangguan","sequence":"additional","affiliation":[{"name":"Department of Urology Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510515 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxue","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510515 P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510515 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510515 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510515 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Nanfang Hospital Southern Medical University  Guangzhou Guangdong 510515 P. R. 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