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However, the complex gastrointestinal environment poses considerable challenges for conventional nanomaterials in achieving targeted accumulation and controlled drug release. Herein, a kind of novel probiotic\u2010enhanced porous bio\u2010hybrids\u00a0(E\u2010\n                    <jats:italic>x<\/jats:italic>\n                    PAM@ASA) is designed via bio\u2010hybridization of 5\u2010aminosalicylic acid\u2010loaded hairy microporous nanospheres (\n                    <jats:italic>x<\/jats:italic>\n                    PAM@ASA) with probiotic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    Nissle 1917. Benefiting from the intrinsic inflammatory\u2010targeting capability of EcN, the E\u2010\n                    <jats:italic>x<\/jats:italic>\n                    PAM@ASA can accumulate in the inflammatory sites of the intestine. The unique porous architecture of\n                    <jats:italic>x<\/jats:italic>\n                    PAM@ASA not only facilitates high drug loading and long\u2010term release but also provides abundant adsorption sites for effective reactive oxygen species scavenging. In a dextran sulfate sodium\u2010induced ulcerative colitis murine model, E\u2010\n                    <jats:italic>x<\/jats:italic>\n                    PAM@ASA demonstrate superior therapeutic outcomes, including mucosal repair, inflammation alleviation, and microbiota regulation. These findings highlight the potential of the multifunctional nanocomposite as a precise therapeutic platform for the treatment of intestinal inflammation.\n                  <\/jats:p>","DOI":"10.1002\/advs.202504802","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T09:56:34Z","timestamp":1751018194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Probiotic\u2010Enhanced Porous Bio\u2010Hybrids with Inflammatory Targeting, ROS Scavenging, and Long\u2010Term Drug Release for Ulcerative Colitis Treatment"],"prefix":"10.1002","volume":"12","author":[{"given":"Luna","family":"Quan","sequence":"first","affiliation":[{"name":"PCFM Lab School of Chemistry Sun Yat\u2010sen University  Guangzhou 510006 P. R. 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