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BPB (Bisphenol B), an extensively used endocrine disrupting chemical, has been widely detected out in human. Migrasomes are newly identified cellular organelles with a large number of unknown functions. However, whether and how BPB exposure may suppress migrasome formation (MF) to induce miscarriage are completely unknown. In this study, it is found that higher urinary BPB levels are associated with the suppressed MF in villous tissues and unexplained miscarriage. It is further confirmed that BPB exposure suppresses MF in the mouse placenta and thus induces miscarriage. Supplement with Pkca or Tspan4, two essential proteins for migration\/invasion (MI) and MF, can efficiently treat against BPB\u2010induced miscarriage. In biological mechanisms, BPB up\u2010regulates ER levels, enhances its interactions with the lnc\u2010HZ04 promoter region, and thus promotes ER\u2010mediated lnc\u2010HZ04 transcription. Subsequently, lnc\u2010HZ04 suppresses TCF4\u2010mediated PKCA transcription and subsequently suppresses MI and MF. Collectively, this study not only identifies BPB as a novel risk factor for unexplained miscarriage, discovers novel pathogenesis and biological mechanisms in BPB\u2010induced miscarriage, but also provides potential targets for treatment against unexplained miscarriage.<\/jats:p>","DOI":"10.1002\/advs.202504871","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T03:05:36Z","timestamp":1763780736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bisphenol B Exposure Induces Miscarriage by Suppressing Migration\/Invasion and Migrasome Formation"],"prefix":"10.1002","volume":"13","author":[{"given":"Wenxin","family":"Huang","sequence":"first","affiliation":[{"name":"Research Center for Environment and Female Reproductive Health The Eighth Affiliated Hospital Sun Yat\u2010sen University  Shenzhen 518033 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