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Using murine pain models, it is demonstrated that MSC effectively alleviates pain, with efficacy comparable to dexmedetomidine, a moderate analgesic. Mechanistically, peripheral delivery of MSC\u2010activated pulmonary\n                    <jats:italic>Npy2r<\/jats:italic>\n                    \u2010expressing vagal sensory neurons, which project to the nucleus tractus solitarius and ventral lateral periaqueductal gray area, drives analgesia via the vagal lung\u2010to\u2010brain pathway. Chemogenetic activation of\n                    <jats:italic>Npy2r<\/jats:italic>\n                    sensory neurons similarly ameliorates spared nerve injury (SNI)\u2010induced mechanical allodynia and thermal hyperalgesia. Furthermore, it is found that MSC\u2010derived extracellular ATP, released via pannexin1, activates\n                    <jats:italic>Npy2r<\/jats:italic>\n                    sensory neurons through purinergic receptor P2X2 (P2rx2). Strikingly, inhalation of a P2rx2 agonist produced significant therapeutic effects in SNI mice. Together, these findings reveal that\n                    <jats:italic>Npy2r<\/jats:italic>\n                    sensory neuron\u2010mediated lung\u2013brain axis underlies MSC\u2010induced analgesia and highlight the potential of targeting body\u2013brain pathways for novel NP treatments.\n                  <\/jats:p>","DOI":"10.1002\/advs.202504922","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:30:48Z","timestamp":1756377048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mesenchymal Stromal Cells Play an Analgesic Role Through a\n                    <i>Npy2r<\/i>\n                    Sensory Neuron\u2010Mediated Lung\u2010to\u2010Brain Axis"],"prefix":"10.1002","volume":"12","author":[{"given":"Jing","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong 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