{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:58:32Z","timestamp":1782187112143,"version":"3.54.5"},"reference-count":65,"publisher":"Wiley","issue":"39","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52375336"],"award-info":[{"award-number":["52375336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011262","name":"State Key Laboratory of Oral Disease","doi-asserted-by":"publisher","award":["SKLOD2024OF05"],"award-info":[{"award-number":["SKLOD2024OF05"]}],"id":[{"id":"10.13039\/501100011262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Modern orthodontics since 1899 has failed to solve rapid and persistent dentition maintenance after tooth movement till now. Traditional post\u2010orthodontic retention using single mechanical fixation cannot actuate periodontal tissue remodel, causing lifelong dependence, huge time costs and discomforts. Current attempts by combining hormone drug with mechanical fixation for improvement are\u00a0limited by unsatisfactory outcomes and global side effects. Targeting at this 120\u2010year dilemma, a flexible magnetoelectric orthodontic retainer (FMOR) is presented using customized additive manufacturing, serving as periodontal remodeler for high\u2010performance post\u2010orthodontic retention. Wireless magnetoelectric cues display considerable effects in periodontal microenvironment remodel, switching periodontal ligament cell (PDLC) paracrine manner to promote M2 macrophage formation, osteoclastic\/osteoblastic balance and collagen metabolism. Using rat and rabbit orthodontic model, application of FMOR is confirmed to significantly strengthen the maintaining of tooth movement outcomes. Mechanistically, magnetoelectric treatment significantly upregulate PDLC genes related to immune response, extracellular matrix organization and osteogenic regulation. This study proposes a non\u2010destructive physical therapeutic strategy for fast activation of periodontal reconstruction after orthodontic treatment and inhibition of tooth relapse for the first time, shedding light on development of next\u2010generation orthodontic retention system for optimized solution of orthodontic relapse.<\/jats:p>","DOI":"10.1002\/advs.202505020","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T09:32:21Z","timestamp":1753263141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Additive Manufactured Magnetoelectric Wireless Retainer as the Periodontal Remodeler for Post\u2010Orthodontic Tissue Reconstruction and Relapse\u2010Inhibition"],"prefix":"10.1002","volume":"12","author":[{"given":"Haoqi","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Stomatology Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"School of Stomatology Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Stomatology Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"School of Stomatology Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials Processing and Die &amp; Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"School of Stomatology Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Stomatology Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"School of Stomatology Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqiang","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Stomatology Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan 430022 China"},{"name":"Department of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"School of Stomatology Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Han","sequence":"additional","affiliation":[{"name":"School of Stomatology Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-8990","authenticated-orcid":false,"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"},{"name":"School of Stomatology Tongji Medical College Huazhong University of Science and Technology  Wuhan 430030 China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-6694","authenticated-orcid":false,"given":"Bin","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Materials Processing and Die &amp; Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-024-00299-8"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-021-00125-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-021-3012-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-46668-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-023-00774-x"},{"key":"e_1_2_9_6_1","volume":"5","author":"Martin C.","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_9_7_1","first-page":"230","volume":"10","author":"Lyros I.","year":"2023","journal-title":"Children (Basel)"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2015.47"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-021-00281-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008207.2011.628060"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(67)90118-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425912440598"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65089-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211016285"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13519"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516685527"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13763"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800121101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jmicro.a023661"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303405"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b02247"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.08.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39315-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-023-00469-5"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.01.003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adl1102"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06627-y"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06631.2002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b07038"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39744-3"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02671-6"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.147931"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411698"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade4687"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S216365"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408473"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c03539"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c11654"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307546"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202201127"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03385"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40846-024-00904-5"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.measurement.2020.107700"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1109\/TPEL.2017.2735441"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1109\/JPROC.2013.2252453"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sna.2020.112269"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202510353"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41928-024-01138-8"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01680-4"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211019949"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-024-00284-1"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjn020"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514553817"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1409-4"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601214"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c04168"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12368"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6200"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.08.009"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02798-6"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04146-3"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02320-y"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12175"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2017.1328613"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.2319\/103117-736.1"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202505020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202505020","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202505020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:05:47Z","timestamp":1773083147000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202505020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":65,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/advs.202505020"],"URL":"https:\/\/doi.org\/10.1002\/advs.202505020","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"2025-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05020"}}