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Here, a stiffness\u2010tunable polyimide probe, termed Neurotentacle, is proposed for deep brain implantation. Its tunability is enabled by embedded microchannels with controllable liquid pressure. During insertion, the Neurotentacle becomes stiff under elevated internal pressure, allowing penetration of brain tissue without additional materials or tools. Once inserted, it regains flexibility by reducing the internal pressure. The novel ultra\u2010thin microchannel fabrication technique enables the Neurotentacle to maintain dimensions similar to conventional flexible probes. This minimizes tissue damage during insertion while ensuring long\u2010term biocompatibility and stability, confirmed by histological evaluations in both acute and chronic animal models. In long\u2010term recordings, Neurotentacles outperform traditional shuttle\u2010assisted implantation methods. The technique is straightforward, controllable, and does not require complex devices, making it ideal for minimally invasive implantation and long\u2010term neural recordings.<\/jats:p>","DOI":"10.1002\/advs.202505100","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T10:04:12Z","timestamp":1753092252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Stiffness\u2010Tunable Neurotentacles for Minimally Invasive Implantation and Long\u2010Term Neural Activity Recordings"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7400-6785","authenticated-orcid":false,"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Solid State Optoelectronics Information Technology Institute of Semiconductors Chinese Academy of Sciences  Beijing 100083 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology Chinese Academy of Sciences  Beijing 100101 China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Solid State Optoelectronics Information Technology Institute of Semiconductors Chinese Academy of Sciences  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyu","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory of Solid State Optoelectronics Information Technology Institute of Semiconductors Chinese Academy of Sciences  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Solid State Optoelectronics Information Technology Institute of Semiconductors Chinese Academy of Sciences  Beijing 100083 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zang","sequence":"additional","affiliation":[{"name":"Foreign Language Teaching and Research Press  Beijing 100089 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Solid State Optoelectronics Information Technology Institute of Semiconductors Chinese Academy of Sciences  Beijing 100083 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Science and Mental Health Institute of Psychology Chinese Academy of Sciences  Beijing 100101 China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-0199","authenticated-orcid":false,"given":"Weihua","family":"Pei","sequence":"additional","affiliation":[{"name":"Laboratory of Solid State Optoelectronics Information Technology Institute of Semiconductors Chinese Academy of Sciences  Beijing 100083 China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195388855.001.0001"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01329-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav2842"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0292-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009955222114"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41378-023-00550-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2006.08.035"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneng.2014.00010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/JMEMS.2020.3000235"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4427"},{"key":"e_1_2_9_11_1","first-page":"9","volume":"5","author":"Wei X. 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