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To address these, a reconstruction system is presented for upper limb motor function, employing highly pressure\u2010sensitive liquid metal magnetorheological elastomers (LMMRE\uff09\u00a0to detect muscle surface pressure. It can dynamically modulate functional electrical stimulation based on muscle force signals, enabling continuous execution of wrist movements for stroke patients. The system markedly improves patient mobility, with wrist lifting angles increased from 14\u00b0 to 47\u00b0, and lifting speed nearly doubled. Clinical trials confirm the system's superior efficacy in promoting motor recovery and reducing muscle spasms. Moreover, functional near\u2010infrared spectroscopy highlights enhanced brain activity and promotes reconstruction of damaged neural pathways during LMMRE\u2010FES therapy compared with the conventional electrical stimulation. This system holds immense potential for advancing stroke rehabilitation, paving the way for portable, wearable devices optimized for home\u2010based care.<\/jats:p>","DOI":"10.1002\/advs.202505259","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T08:34:02Z","timestamp":1752222842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Upper Limb Motor Function Rehabilitation System Leveraging Pressure\u2010Sensitive Intent Recognition"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7828-5998","authenticated-orcid":false,"given":"Zhiwei","family":"Hu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of USTC, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Institute of Humanoid Robots, Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5787-8116","authenticated-orcid":false,"given":"Yongchao","family":"Yin","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xing","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Institute of Humanoid Robots, Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwu","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Institute of Humanoid Robots, Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Gong","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230001 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-3777","authenticated-orcid":false,"given":"Guolin","family":"Yun","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-9217","authenticated-orcid":false,"given":"Shuaishuai","family":"Sun","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC, CAS Key Laboratory of Mechanical Behavior and Design of Materials, Institute of Humanoid Robots, Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China  Hefei Anhui 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","volume":"76","author":"Roth G. 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