{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:59:14Z","timestamp":1792371554083,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017544","name":"Health and Family Planning Commission of Lianyungang City","doi-asserted-by":"publisher","award":["L202410"],"award-info":[{"award-number":["L202410"]}],"id":[{"id":"10.13039\/501100017544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017544","name":"Health and Family Planning Commission of Lianyungang City","doi-asserted-by":"publisher","award":["QN202413"],"award-info":[{"award-number":["QN202413"]}],"id":[{"id":"10.13039\/501100017544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurological diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, pose a significant global health challenge due to their complex pathogenesis and widespread prevalence. These disorders are often associated with disruptions in neurotransmitter regulation, leading to progressive cognitive and motor impairments. Conventional diagnostic methods are time\u2010consuming and lack the sensitivity required for early\u2010stage detection. Herein, for the first time a novel photoresponsive nanozyme sensor array is presented that integrates metal\u2010organic frameworks (MOFs) and machine learning algorithms for the rapid, sensitive, and multiplexed detection of neurotransmitters. Wherein, Zn(II) meso\u2010Tetra(4\u2010carboxyphenyl)porphine (ZnTCPP) \u2010based MOFs, with their large specific surface area, enhance the interaction between reactant substrates and catalytic active sites within the material, significantly improving response sensitivity. Additionally, light\u2010driven catalysis greatly accelerates the response speed of the nanozyme. Mimicking the mammalian olfactory system, the array responds to various neurotransmitters in a patterned manner, enabling accurate differentiation and quantification within minutes. It maintains high precision even in complex biological samples such as serum and cerebrospinal fluid. The biomimetic sensor can detect neurotransmitter signatures linked to neurological disorders, such as Alzheimer's disease. This platform offers significant potential for early diagnosis and continuous monitoring of neurological conditions.<\/jats:p>","DOI":"10.1002\/advs.202505333","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T23:40:05Z","timestamp":1751845205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Biomimetic Analysis of Neurotransmitters for Disease Diagnosis through Light\u2010Driven Nanozyme Sensor Array and Machine Learning"],"prefix":"10.1002","volume":"12","author":[{"given":"Kun","family":"Yu","sequence":"first","affiliation":[{"name":"Lianyungang Clinical College Jiangsu University &amp; The Second People's Hospital of Lianyungang  Lianyungang 222006 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine Jining Medical University  Jining 272067 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiwen","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine Jining Medical University  Jining 272067 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzun","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine Jining Medical University  Jining 272067 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aobing","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine Jining Medical University  Jining 272067 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine Jining Medical University  Jining 272067 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences &amp; Institute of Materia Medica Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan 250062 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuzhu","family":"Gao","sequence":"additional","affiliation":[{"name":"Lianyungang Clinical College Jiangsu University &amp; The Second People's Hospital of Lianyungang  Lianyungang 222006 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Basic Medicine Jining Medical University  Jining 272067 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2111-5251","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Medical Engineering Jining Medical University  Jining 272067 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,6]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00915-x"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-00955-x"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3875"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2322550121"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-022-00577-6"},{"key":"e_1_2_8_2_4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04615-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c05082"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202406401"},{"key":"e_1_2_8_3_3","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.3c00326"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c02740"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnanoscienceau.2c00039"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60477B"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2022.116541"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104614"},{"key":"e_1_2_8_5_4","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.3c00082"},{"key":"e_1_2_8_5_5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20413-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300309"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.136272"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114211"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c06952"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c10203"},{"key":"e_1_2_8_7_3","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c10390"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318483"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.2c02596"},{"key":"e_1_2_8_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202006230"},{"key":"e_1_2_8_8_4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00226"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12959"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00160"},{"key":"e_1_2_8_9_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c11333"},{"key":"e_1_2_8_9_4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202203224"},{"key":"e_1_2_8_9_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.109813"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c00670"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00026"},{"key":"e_1_2_8_10_3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410751"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-024-01947-4"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400207"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.4c03933"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216506"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.140779"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c03610"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00844"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.149621"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c01932"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC02113E"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7TA07911G"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2023.135046"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202505333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202505333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202505333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:42:03Z","timestamp":1773344523000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202505333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,6]]},"references-count":46,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/advs.202505333"],"URL":"https:\/\/doi.org\/10.1002\/advs.202505333","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,6]]},"assertion":[{"value":"2025-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05333"}}