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Here, the synthesis of two new DELs, named FM\u2010DEL1 and FM\u2010DEL2, including 7\u2032710 and 5\u2032697\u2019690 compounds, respectively is described. These libraries are constructed by installing one or two sets of building blocks on a phenylalanine central scaffold. FM\u2010DELs are screened against markers of prostate cancer, and renal cell carcinoma, and against an immunological target expressed on the surface of natural killer cells. Highly potent and selective binders with affinity constants in the nanomolar range are obtained from DEL screenings against those targets. Small\u2010molecule ligands against tumor\u2010associated antigens are used to develop small\u2010molecule radiopharmaceuticals that selectively accumulate at cancer sites after systemic administration.<\/jats:p>","DOI":"10.1002\/advs.202505351","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T01:31:23Z","timestamp":1751247083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phenylalanine\u2010Based DNA\u2010Encoded Chemical Libraries for the Discovery of Potent and Selective Small Organic Ligands Against Markers of Cancer and Immune Cells"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-978X","authenticated-orcid":false,"given":"Francesca","family":"Migliorini","sequence":"first","affiliation":[{"name":"Philochem AG  Otelfingen CH\u20108112 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