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Despite progress made with small molecule antioxidants and nanozymes, effective antioxidant therapy for the long\u2010term elimination of these ROS remains challenging, largely due to the rapid clearance of antioxidants from the joints via synovial vessels and lymphatics. Herein, a molten\u2010salt method is developed to facilitate the atomic dispersion of Mn or Co ions homogeneously on the surface of akermanite microparticles (AKT\u2010MPs). The micrometer\u2010scale Mn\u2010 or Co\u2010AKT\u2010MPs with multi\u2010mimetic enzyme effects are demonstrated to obliterate multiple ROS, thereby protecting the inherent homeostasis between chondrocyte anabolism and catabolism, while suppressing the conversion of macrophages to a pro\u2010inflammatory phenotype. In addition, the microparticles exhibited chondroprotection of ROS\u2010challenged cartilage explants in vitro by limiting the loss of cartilage extracellular matrix (ECM) and the release of degradative enzymes. Furthermore, Mn\u2010 or Co\u2010AKT\u2010MPs are injected intra\u2010articularly into monosodium iodoacetate (MIA)\u2010induced OA mice and effectively suppress synovial inflammation, painful symptoms, and progression of early cartilage destruction. Therefore, this microparticle\u2010based antioxidant therapy provides an insight and paradigm to control atomic catalysts integrated with microparticles for efficient catalytic anti\u2010OA treatments.<\/jats:p>","DOI":"10.1002\/advs.202505500","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T08:50:57Z","timestamp":1753087857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Molten\u2010Salt\u2010Mediated Synthesis of Atomic Manganese\/Cobalt Catalysts on Bioceramic Microparticles for Catalytic Anti\u2010Osteoarthritis Treatments"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1282-8289","authenticated-orcid":false,"given":"Ronghui","family":"Deng","sequence":"first","affiliation":[{"name":"Sports Medicine Department Beijing Key Laboratory of Sports Injuries Peking University Third Hospital  Beijing 100191 P. R. 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