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The subsequent replacement of necrotic myocardium with fibrotic tissue disrupts normal electrophysiological conduction pathways. This study develops a multifunctional hydrogel, TAlg\/PEDOT@PMOF, incorporating an integrated PEDOT@PMOF nanofiller designed to simultaneously scavenge ROS and restore electrical coupling following myocardial infarction (MI). The ROS\u2010neutralizing capability of the nanofiller stems from the manganese porphyrin, which closely emulates the catalytically active site of native antioxidant enzymes. To increase electrical conductivity, the conductive polymer PEDOT is immobilized onto the MOF structure via a polydopamine (PDA) adhesion layer. Furthermore, the hydrogel network is functionalized with cell\u2010adhesion peptides, enabling a synergistic enhancement of ROS clearance and electrical signal transmission by the nanofiller at both the cellular and tissue scales. This dual functionality is evidenced by improved cytoprotection under oxidative stress, enhanced calcium transient in cardiomyocytes, restoration of cardiac function, and reduced susceptibility to arrhythmia. These results establish an effective strategy for engineering an integrated enzyme\u2010mimicking system and highlight a practical and innovative approach for future MI therapy.<\/jats:p>","DOI":"10.1002\/advs.202505612","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T03:40:52Z","timestamp":1757734852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Redox\u2010Active and Electroactive Hydrogel Enabled by an Integrated PEDOT@PMOF Nanofiller for Post\u2010Infarct Myocardial Repair"],"prefix":"10.1002","volume":"12","author":[{"given":"Shuyi","family":"He","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyu","family":"Long","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for 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