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While historical research has largely focused on the osseous abnormalities associated with DDH, current surgical interventions, though prevalent, often carry significant and unavoidable side effects. To break through these limitations, the study delved into the acetabular labrum, a crucial intra\u2010articular structure that presents abnormalities in DDH patients. Through single\u2010cell combined spatial transcriptomic analysis of the acetabular labrum under diverse conditions, a comprehensive examination of the changes of DDH tissue changes at the single\u2010cell level is pioneered, conclusively linking aberrant fibrocartilage stem\/progenitor cell proliferation to disease progression. The subsequent in vivo and in vitro experiments unequivocally identify the MK signaling pathway as a pivotal target for DDH treatment. Localized administration of its specific inhibitor not only substantially alleviates early structural abnormalities in DDH but also lays a robust and promising foundation for the innovation and clinical translation of new therapeutic strategies for DDH. In summary, the findings not only deepen the understanding of DDH pathogenesis but also pave the way for innovative therapeutic strategies that prioritize both efficacy and safety.<\/jats:p>","DOI":"10.1002\/advs.202505803","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T02:55:13Z","timestamp":1751511313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip"],"prefix":"10.1002","volume":"12","author":[{"given":"Runze","family":"Yang","sequence":"first","affiliation":[{"name":"Sports Medicine Center Department of Orthopedic Surgery\/Orthopedic Research Institute West China Hospital Sichuan University  Chengdu Sichuan 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianfu Jiangxi Laboratory  Chengdu Sichuan 641419 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghao","family":"Ge","sequence":"additional","affiliation":[{"name":"Sports Medicine Center Department of Orthopedic Surgery\/Orthopedic Research Institute West China Hospital Sichuan University  Chengdu Sichuan 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianfu Jiangxi Laboratory  Chengdu Sichuan 641419 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Xu","sequence":"additional","affiliation":[{"name":"Sports Medicine Center Department of Orthopedic Surgery\/Orthopedic Research Institute West China Hospital Sichuan University  Chengdu Sichuan 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sports Medicine Center Department of Orthopedic Surgery\/Orthopedic Research Institute West China Hospital Sichuan University  Chengdu Sichuan 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Sports Medicine Center Department of Orthopedic Surgery\/Orthopedic Research Institute West China Hospital Sichuan University  Chengdu Sichuan 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu Sichuan 610054 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Sports Medicine Center Department of Orthopedic Surgery\/Orthopedic Research Institute West China Hospital Sichuan University  Chengdu Sichuan 610064 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology University of Electronic Science and Technology of China  Chengdu Sichuan 610054 China"},{"name":"Tianfu Jiangxi Laboratory  Chengdu Sichuan 641419 China"},{"name":"GenomCan Inc.  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