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Whilst the effect of cell\u2010type heterogeneity on epigenetic clock estimates has been explored, such studies have been limited to studying heterogeneity within the adaptive immune system. Much less is known about whether heterogeneity within the innate immune system can impact epigenetic clock estimates and their associations with health outcomes. Here, we apply a high\u2010resolution DNAm reference panel of 19 immune cell\u2010types, including young and adult monocyte, natural killer, and neutrophil subsets, demonstrating how shifts within these innate subtypes display associations with epigenetic clock acceleration, inflammaging, and all\u2010cause mortality. The associations of monocyte heterogeneity with inflammation are further validated using transcriptomic and metabolomic data. 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