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This study hypothesizes that autophagy exerts a protective effect, inhibiting adhesion formation following tendon injury. Furthermore, it is proposed that interleukin\u201037 (IL\u201037) can be a potential therapeutic target for preventing tendon adhesions through autophagy activation. Therefore, an innovative three\u2010layer composite antiadhesion barrier (pDNA@E\u2013H\u2013E\u2032) equipped with on\u2010demand and unidirectional delivery strategy of bioactive plasmid DNA (pDNA) for IL\u201037 overexpression is designed. The novel finding of the fibroblast's autophagy activity as a protective factor in tendon adhesion highlights the encapsulation of IL\u201037\u2010encoding pDNA nanocomposites in barrier for reaching supreme antiadhesion efficacy. Moreover, the reactive\u2010oxygen\u2010species\u2010responsive and releasing\u2010direction\u2010guided pDNA@E\u2013H\u2013E\u2032 membranes afford wonderful inhibition of fibroblast proliferation, fibroblast\u2010to\u2010myofibroblast differentiation, and collagen synthesis by enhancing autophagy. Further in a rat Achilles tendon adhesion model, pDNA@E\u2013H\u2013E\u2032 membranes also significantly suppress peritendinous adhesion formation on the repaired sites and promote the scarless repair of Achilles tendon with optimum efficiency. In all, this study provides a promising approach for preventing tendon adhesion by employing a composite barrier with on\u2010demand and unidirectional delivery strategy.<\/jats:p>","DOI":"10.1002\/advs.202506204","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T03:30:28Z","timestamp":1757647828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Composite Antiadhesion Barrier Facilitated Fibroblast Autophagy Activation for Tendon Repair"],"prefix":"10.1002","volume":"12","author":[{"given":"Zhenyu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 200233 P. R. 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