{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:13:45Z","timestamp":1791580425969,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22074066"],"award-info":[{"award-number":["22074066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The tumor microenvironment (TME) significantly restricts chemodynamic therapy (CDT) efficacy through hypoxia and antioxidant defenses. An intelligent cascade nanosystem, PTA\u2010SnS\n                    <jats:sub>2<\/jats:sub>\n                    @GOx, is developed by integrating a tannic acid\u2010modified Prussian blue analogue core, SnS\n                    <jats:sub>2<\/jats:sub>\n                    shell, and glucose oxidase (GOx) activation module. The needle\u2010like nanostructure enhanced tumor accumulation and cellular uptake. GOx\u2010mediated glucose oxidation generated H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and gluconic acid, triggering pH\u2010responsive H\n                    <jats:sub>2<\/jats:sub>\n                    S release from SnS\n                    <jats:sub>2<\/jats:sub>\n                    . This gas disrupted mitochondrial respiration and catalase activity, alleviating hypoxia while elevating intracellular H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    levels. The oxygenated TME subsequently amplified GOx biocatalysis, establishing a self\u2010sustaining cycle of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    production and acidification. Concurrently, Sn\n                    <jats:sup>4+<\/jats:sup>\n                    ions depleted glutathione, synergistically enhancing Fenton\u2010like reactions in the PTA core for reinforced ROS generation. This multi\u2010tiered strategy achieved effective CDT through the coordinated mechanisms: continuous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    self\u2010supply, pH reduction, and redox homeostasis disruption. Notably, the nanosystem induced immunogenic cell death, promoting dendritic cell maturation and repolarizing tumor\u2010associated macrophages from M2 to M1 phenotype, thereby remodeling immunosuppressive TME and activating systemic antitumor immunity. The synergistic integration of self\u2010amplifying CDT with immune sensitization demonstrates superior tumor suppression in vivo. This study provided an intelligent paradigm for cancer theranostics by combining self\u2010supplying H\n                    <jats:sub>2<\/jats:sub>\n                    S\/H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010enhanced CDT with sensitized immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.202506282","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T03:49:48Z","timestamp":1747885788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Needle\u2010Like H\n                    <sub>2<\/sub>\n                    S\u2010Releasing and H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    Self\u2010Replenishing Nanoplatform for Enhanced Chemodynamic Tumor Immunotherapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Xiaoxiao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Nanjing Medical University  Nanjing 211166 China"},{"name":"Department of stomatology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing 210008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy Nanjing Medical University  Nanjing 211166 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of stomatology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School  Nanjing 210008 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