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However, inducing bacterial cuproptosis\u2010like death using low concentrations of copper (Cu) ions remains a challenge. Therefore, a \u201cherbal\u2010piezoelectric heterojunction\u201d (Herbal\u2010Piezo\u2010HJ) is designed by integrating berberine (Ber) with Cu ion\u2010doped Strontium titanate (SrTiO\n                    <jats:sub>3<\/jats:sub>\n                    , STO) on a Ti substrate (STO\u2010Cu@Ber). Ber and acoustoelectric therapy (SPT) synergistically enhance the efficacy of low\u2010concentration Cu ions in inducing bacterial cuproptosis\u2010like death. The formation of inorganic\/organic heterojunctions significantly enhances piezoelectric performance, generating marked electronic asymmetry at the interface under ultrasonic (US) irradiation and producing a large amount of reactive oxygen species (ROS). ROS and Ber together damage bacterial cell walls and membranes, promoting Cu ion uptake into bacterial cells. Consequently, the bacterial glycolytic respiratory mode is altered, the tricarboxylic acid cycle is significantly inhibited, and a large amount of nutrients are leaked, resulting in bacterial cuproptosis\u2010like death. Additionally, Herbal\u2010Piezo\u2010HJ downregulates arachidonic acid metabolites, activates the cyclic adenosine monophosphate (cAMP) signaling pathway to resolve the inflammatory response after infection clearance, and promotes bone integration. Overall, the combination of herbal therapy and SPT to enhance bacterial cuproptosis\u2010like death offers a promising strategy for eradicating IAOM.\n                  <\/jats:p>","DOI":"10.1002\/advs.202506362","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:21:24Z","timestamp":1756376484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Herbal\u2010Piezoelectric Heterojunction Strategy to Potentiate Bacterial Cuproptosis\u2010Like Death and Remodel the Inflammatory Microenvironment in Infection\u2010Associated Implant Osteomyelitis"],"prefix":"10.1002","volume":"12","author":[{"given":"Guannan","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Third Hospital of Shanxi Medical University Tongji Shanxi Hospital  Taiyuan 030032 China"},{"name":"Shanxi Provincial Key Laboratory for Translational Nuclear 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