{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:34:02Z","timestamp":1791912842304,"version":"4.3.4"},"reference-count":74,"publisher":"Wiley","issue":"40","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diabetes exacerbates the development and progression of periodontitis through the aggravation of persistent inflammation and tissue destruction. While the impact of diabetes on peripheral sensory nerves is well\u2010documented, little is known about the role of diabetic neuropathy in bone destruction in diabetes\u2010associated periodontitis. Herein, a significant loss of periodontal nerves is observed in the diabetic state of db\/db mice, with trigeminal ganglion neurons showing decreased autophagy. These mice exhibit decreased density of calcitonin gene\u2010related peptide (CGRP)\n                    <jats:sup>+<\/jats:sup>\n                    nerves, correlating with the progression of diabetes and inflammatory state. Furthermore, diabetic mice with periodontitis show greater alveolar bone loss, which can be phenocopied by periodontal denervation. Importantly, CGRP receptor\u2010related components are found to be expressed in periodontal endothelial cells. In both diabetic and denervated periodontium, the loss of CGRP signaling is associated with the reduction of type H vessel density and coupled osterix\n                    <jats:sup>+<\/jats:sup>\n                    osteoprogenitors. To elaborate further, an injectable reactive oxygen species\u2010responsive poly(vinyl alcohol) (PVA)\/tsPBA hydrogel is developed for sustained CGRP delivery. Notably, the CGRP\u2010loaded hydrogels promote alveolar bone regeneration via inducing type H vessel formation in diabetic mice. The findings highlight that diabetes\u2010induced sensory nerve damage may exacerbate periodontitis\u2010induced bone loss, and CGRP@PVA\/tsPBA hydrogels offer a promising therapeutic strategy for bone regeneration.\n                  <\/jats:p>","DOI":"10.1002\/advs.202506438","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T09:01:08Z","timestamp":1754298068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["CGRP\u2010Loaded ROS\u2010Responsive Hydrogel Restores Neuro\u2010Angiogenic Signaling to Promote Bone Regeneration in Diabetes\u2010Associated Periodontitis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1577-761X","authenticated-orcid":false,"given":"Chaoning","family":"Zhan","sequence":"first","affiliation":[{"name":"Division of Paediatric Dentistry and Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Dai","sequence":"additional","affiliation":[{"name":"Division of Paediatric Dentistry and Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhan","family":"Ren","sequence":"additional","affiliation":[{"name":"Division of Paediatric Dentistry and Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4305-1337","authenticated-orcid":false,"given":"Lijian","family":"Jin","sequence":"additional","affiliation":[{"name":"Division of Periodontology &amp; Implant Dentistry Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-3497","authenticated-orcid":false,"given":"Weiping","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pharmaceutical Biotechnology The University of Hong Kong Hong Kong SAR China"},{"name":"Department of Pharmacology &amp; Pharmacy Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China"},{"name":"Laboratory of Molecular Engineering and Nanomedicine Dr. Li Dak\u2010Sum Research Centre The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-0919","authenticated-orcid":false,"given":"Zhou","family":"Ye","sequence":"additional","affiliation":[{"name":"Applied Oral Sciences and Community Dental Care Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0698-7155","authenticated-orcid":false,"given":"James Kit Hon","family":"Tsoi","sequence":"additional","affiliation":[{"name":"Applied Oral Sciences and Community Dental Care Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-9159","authenticated-orcid":false,"given":"Yifan","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Paediatric Dentistry and Orthodontics Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.860274"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14082847"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080669"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12633"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MA0321-745R"},{"key":"e_1_2_9_3_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-00950-2"},{"key":"e_1_2_9_3_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2024.09.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076309"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12912"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02175-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.06.034"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003390"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07237-y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-019-00528-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.01.002"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37041-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-023-00241-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111766"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115464"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301366"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108697"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115736"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27432-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.02.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09639-7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4860-y"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06154-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13400"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13517"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00059.2021"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1778039"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1236545"},{"key":"e_1_2_9_22_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.121972"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345231191745"},{"key":"e_1_2_9_24_1","first-page":"1","author":"Wadan A. 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