{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:20:51Z","timestamp":1790198451039,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Polycystic ovary syndrome (PCOS) is a severe disorder that compromises female ovarian health and elevates the risk of various diseases, including endometrial cancer. The pathogenesis of PCOS remains poorly understood, which has hindered the development of effective interventions. In this study, it is demonstrated that patients with PCOS exhibit significant gut dysbiosis. FMT from PCOS patients (P\u2010FMT) into mice induced PCOS\u2010associated symptoms and histological alterations. Notably, both PCOS patients and P\u2010FMT mice exhibit distinct metabolic profiles in the gut, suggesting a gut microbiota\u2010mediated metabolic reprogramming. Furthermore, impaired tryptophan metabolism, particularly reduced levels of 3\u2010hydroxyanthranilic acid (3\u2010HAA), is observed in both PCOS patients and P\u2010FMT mice. Administration of 3\u2010HAA to mice alleviated DHEA\u2010induced PCOS. Mechanistically, 3\u2010HAA promoted NAD\n                    <jats:sup>+<\/jats:sup>\n                    synthesis via the de novo biosynthesis pathway, thereby inhibiting DHEA\u2010induced ferroptosis by modulating the mitochondrial DNA\u2010cGAS\u2010STING axis. Collectively, these findings reveal the critical role of gut microbiota\u2010mediated NAD\n                    <jats:sup>+<\/jats:sup>\n                    synthesis in the pathogenesis of PCOS, underscoring the potential of targeting gut microbiota and NAD\n                    <jats:sup>+<\/jats:sup>\n                    homeostasis as a therapeutic strategy for PCOS prevention and management.\n                  <\/jats:p>","DOI":"10.1002\/advs.202506497","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T02:59:50Z","timestamp":1760410790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Disruption of Gut Microbiota\u2010Mediated De Novo NAD\n                    <sup>+<\/sup>\n                    Synthesis Contributes to the Development of Polycystic Ovary Syndrome"],"prefix":"10.1002","volume":"12","author":[{"given":"Ke","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gynecology China\u2010Japan Union Hospital of Jilin University  Changchun Jilin 130033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Gynecology China\u2010Japan Union Hospital of Jilin University  Changchun Jilin 130033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gynecology China\u2010Japan Union Hospital of Jilin University  Changchun Jilin 130033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gynecology China\u2010Japan Union Hospital of Jilin University  Changchun Jilin 130033 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