{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:02:02Z","timestamp":1791316922892,"version":"4.3.1"},"reference-count":65,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130015"],"award-info":[{"award-number":["82130015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470312"],"award-info":[{"award-number":["82470312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930012"],"award-info":[{"award-number":["81930012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241027"],"award-info":[{"award-number":["82241027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1441600"],"award-info":[{"award-number":["23ZR1441600"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["XKPF2024A1011"],"award-info":[{"award-number":["XKPF2024A1011"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["XKPF2024A103"],"award-info":[{"award-number":["XKPF2024A103"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["XKPF2024B200"],"award-info":[{"award-number":["XKPF2024B200"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, whose underlying pathogenesis remains largely unclear, and lacks reliable biomarkers or therapeutic targets for early detection and treatment during pregnancy. In this study, we investigated the role of endogenous peptide ELABELA (ELA) in fetal CHD. Our findings reveal that ELA levels are significantly reduced in human fetal cardiac tissues with CHD. In mouse models, ELA deletion in cardiac progenitor cells disrupted mitochondrial function, directly contributing to cardiac malformations. Mechanistically, ELA deficiency caused mitochondrial swelling by inhibiting the APJ\u2010AKT\u2010BCL2\/BAX signaling pathway. Notably, exogenous ELA administration reduced both CHD severity and incidence in mice. Furthermore, plasma ELA levels were markedly down\u2010regulated in human pregnancies with fetal CHD. These findings establish ELA as a crucial regulator of cardiac development and highlight its potential as both a biomarker and therapeutic target for the prevention and management of fetal CHD during gestation.<\/jats:p>","DOI":"10.1002\/advs.202506525","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:03:16Z","timestamp":1775559796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ELABELA Targets Mitochondria to Modulate Heart Development"],"prefix":"10.1002","volume":"13","author":[{"given":"Jian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Engineering Research Center of Medical Devices For Congenital Heart Disease Ministry of Education Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Engineering Research Center of Medical Devices For Congenital Heart Disease Ministry of Education Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Engineering Research Center of Medical Devices For Congenital Heart Disease Ministry of Education Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Engineering Research Center of Medical Devices For Congenital Heart Disease Ministry of Education Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfeng","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Engineering Research Center of Medical Devices For Congenital Heart Disease Ministry of Education Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Department of Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Engineering Research Center of Medical Devices For Congenital Heart Disease Ministry of Education Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ministry of Education\u2010Shanghai Key Laboratory of Children's Environmental Health Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Physiology Basic Medical School Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Diagnosis and Treatment Center For In Utero Pediatric Diseases Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Linyi Maternal and Child Health Care Hospital  Linyi Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell Biology Center For Excellence in Molecular Cell Science Chinese Academy of Sciences University of Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Engineering Research Center of Medical Devices For Congenital Heart Disease Ministry of Education Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Lin He's Academician Workstation of New Medicine and Clinical Translation Jining Medical University  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Ministry of Education\u2010Shanghai Key Laboratory of Children's Environmental Health Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex F.","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-7372","authenticated-orcid":false,"given":"Kun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Institute for Developmental and Regenerative Cardiovascular Medicine Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Engineering Research Center of Medical Devices For Congenital Heart Disease Ministry of Education Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004989\u20103"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.10.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007171\u2010z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dgd.12134"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019501\u2010199710000\u201000003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj\u201010\u20100234"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505143"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.899034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.06.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.87.3.189"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07027"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2013.11.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.873614"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002591"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam6607"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2017.08.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06726"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.014"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/3.1.3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013847"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201034"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20100969\u2010x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100414\u20106"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200202"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092177"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202200221"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.05.016"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010physiol\u2010021115\u2010105011"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2275"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201696179"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003143"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1739264"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_105_18"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017645"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.116.023218"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2016.303484"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.648238"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08170"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001547\u20109"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271301"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.03.003"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311349"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.200458"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0008\u20106363(99)00401\u20100"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20058"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.87.10.856"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.123651"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0008\u20106363(02)00603\u2010x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437597.44550.5d"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12574\u2010016\u20100308\u20102"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca.12.15"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.03.056"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492093"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP2987"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101254155"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo5503"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321398"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050812"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010020\u20100591\u20103"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251487"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.07.035"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.62"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202506525","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202506525","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202506525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:53:37Z","timestamp":1783655617000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202506525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":65,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/advs.202506525"],"URL":"https:\/\/doi.org\/10.1002\/advs.202506525","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e06525"}}