{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:05:54Z","timestamp":1792109154394,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"45","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["22QA1410900"],"award-info":[{"award-number":["22QA1410900"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272116"],"award-info":[{"award-number":["82272116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2021SHZDZX"],"award-info":[{"award-number":["2021SHZDZX"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018AAA0103100"],"award-info":[{"award-number":["2018AAA0103100"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Brain\u2010computer interfaces (BCIs) enable communication between individuals and computers or other assistive devices by decoding brain activity, thereby reconstructing speech and motor functions for patients with neurological disorders. This study presents a high\u2010resolution micro\u2010electrocorticography (\u00b5ECoG) BCI based on a flexible, high\u2010density \u00b5ECoG electrode array, capable of chronically stable and real\u2010time motor decoding. Leveraging micro\u2010nano manufacturing technology, the \u00b5ECoG BCI achieves a 64\u2010fold increase in electrode density compared to conventional clinical electrode arrays, enhancing spatial resolution while featuring scalability. Over a 203\u2010day in vivo experiment, high\u2010resolution \u00b5ECoG carrying fine spatial specificity information demonstrated the potential to improve decoding performance while reduce implanted devices size. These advancements provide a pathway to overcome the limitations of conventional ECoG BCIs. During awake surgery, the \u00b5ECoG BCI enabled game control after 7 min of model training. Furthermore, during practice of 19.87 h, the participant achieved cursor control with a bit rate of 1.13 bits per second (BPS) under full volitional control, and the bit rate reached up to 4.15 BPS with enhanced user interface. These results show that the \u00b5ECoG BCI achieves comparable performance to intracortical electroencephalographic (iEEG) BCIs without intracortical invasiveness, marking a breakthrough in the clinical feasibility of flexible BCIs.<\/jats:p>","DOI":"10.1002\/advs.202506663","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T11:41:53Z","timestamp":1757158913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Chronically Stable, High\u2010Resolution Micro\u2010Electrocorticographic Brain\u2010Computer Interfaces for Real\u2010Time Motor Decoding"],"prefix":"10.1002","volume":"12","author":[{"given":"Erda","family":"Zhou","sequence":"first","affiliation":[{"name":"2020 X\u2010Lab Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences  Shanghai 200050 China"},{"name":"School of Graduate Study University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiner","family":"Wang","sequence":"additional","affiliation":[{"name":"2020 X\u2010Lab Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences  Shanghai 200050 China"},{"name":"School of Graduate Study University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhi","family":"Liang","sequence":"additional","affiliation":[{"name":"2020 X\u2010Lab Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences  Shanghai 200050 China"},{"name":"School of Graduate Study University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Neuroxess Co., Ltd.  Shanghai 200023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinrong","family":"Yang","sequence":"additional","affiliation":[{"name":"Neuroxess Co., Ltd.  Shanghai 200023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Ran","sequence":"additional","affiliation":[{"name":"Neuroxess Co., Ltd.  Shanghai 200023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xia","sequence":"additional","affiliation":[{"name":"Neuroxess Co., Ltd.  Shanghai 200023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital of Fudan University  Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Liu","sequence":"additional","affiliation":[{"name":"2020 X\u2010Lab Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences  Shanghai 200050 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyang","family":"Sun","sequence":"additional","affiliation":[{"name":"2020 X\u2010Lab Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences  Shanghai 200050 China"},{"name":"School of Integrated Circuits University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Peng","sequence":"additional","affiliation":[{"name":"Neuroxess Co., Ltd.  Shanghai 200023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital of Fudan University  Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital of Fudan University  Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Huashan Hospital of Fudan University  Shanghai 200040 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6583-5039","authenticated-orcid":false,"given":"Tiger H.","family":"Tao","sequence":"additional","affiliation":[{"name":"Neuroxess Co., Ltd.  Shanghai 200023 China"},{"name":"Guangdong Institute of Intelligence Science and Technology  Zhuhai Guangdong 519031 China"},{"name":"Tianqiao and Chrissy Chen Institute for Translational Research  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-4461","authenticated-orcid":false,"given":"Zhitao","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Graduate Study University of Chinese Academy of Sciences  Beijing 100049 China"},{"name":"School of Integrated Circuits University of Chinese Academy of Sciences  Beijing 100049 China"},{"name":"State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences  Shanghai 200050 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3109\/02699052.2015.1004750"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2022.3164075"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-04390-w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd0380"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06094-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3241"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42490-019-0022-z"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2021.3106897"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085192"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2019.2953121"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/12\/3\/036009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/10\/5\/056005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04970"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18554"},{"key":"e_1_2_9_15_1","first-page":"1189","volume":"3","author":"Chao Z. C.","year":"2010","journal-title":"Front. Neuroeng."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/9\/4\/046003"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/13\/2\/026021"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0662-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.02.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2024.110251"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06443-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1119-1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/ab9986"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1601027"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2917-18.2019"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/abd460"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42555-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801617"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0209-y"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/aa9ee7"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2168160"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112467"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0250296"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2848-08.2008"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2009.2023307"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.04.022"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2017.00062"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202506663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T09:58:49Z","timestamp":1767607129000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202506663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,6]]},"references-count":38,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/advs.202506663"],"URL":"https:\/\/doi.org\/10.1002\/advs.202506663","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,6]]},"assertion":[{"value":"2025-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e06663"}}