{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:42:39Z","timestamp":1775983359727,"version":"3.50.1"},"reference-count":94,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010446","name":"Institute for Basic Science","doi-asserted-by":"publisher","award":["IBS\u2010R029\u2010C2"],"award-info":[{"award-number":["IBS\u2010R029\u2010C2"]}],"id":[{"id":"10.13039\/501100010446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010446","name":"Institute for Basic Science","doi-asserted-by":"publisher","award":["IBS\u2010R030\u2010C1"],"award-info":[{"award-number":["IBS\u2010R030\u2010C1"]}],"id":[{"id":"10.13039\/501100010446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201000523615"],"award-info":[{"award-number":["RS\u20102025\u201000523615"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000222762"],"award-info":[{"award-number":["RS\u20102023\u201000222762"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000342560"],"award-info":[{"award-number":["RS\u20102024\u201000342560"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Interferon\u2010\u03bb (IFN\u2010\u03bb), a type III interferon that selectively targets epithelial cells, holds strong potential as an intranasal antiviral due to its ability to suppress respiratory virus replication without inducing systemic inflammation. However, clinical translation of human IFN\u2010\u03bb3 (hIFN\u2010\u03bb3) is hindered by limited thermostability, protease susceptibility, and rapid mucosal clearance. In this study, instability\u2010prone elements in hIFN\u2010\u03bb3 are eliminated through artificial intelligence (AI)\u2010based backbone remodeling and targeted surface hydrophobic patch engineering. A protease\u2010sensitive loop is replaced with a\n                    <jats:italic>de novo<\/jats:italic>\n                    \u03b1\u2010helix, which shields neighboring hydrophobic patches and forms a new hydrophobic core, yielding an engineered variant (hIFN\u2010\u03bb3\u2010DE1) with enhanced thermostability (Tm &gt;\u00a090\u00a0\u00b0C), protease resistance, and preserved antiviral activity and structural integrity even after extended heat stress (two weeks at 50\u00a0\u00b0C). Further glyco\u2010engineering introduces an N\u2010linked glycan at a site distant from receptor\u2010binding interfaces, improving solubility, production yield, and diffusion through synthetic nasal mucus. Intranasal administration of the resulting variant (G\u2010hIFN\u2010\u03bb3\u2010DE1) enables effective mucosal penetration and provides a more rapid onset of in vivo prophylactic protection against influenza A virus. These findings highlight a robust and versatile strategy that combines AI\u2010driven structural design with glyco\u2010engineering to develop scalable, bioavailable, and functionally enhanced nasal biologics for respiratory virus prophylaxis.\n                  <\/jats:p>","DOI":"10.1002\/advs.202506764","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:27:31Z","timestamp":1763630851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Computational Design and Glycoengineering of Interferon\u2010Lambda for Nasal Prophylaxis Against Respiratory Viruses"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-2564","authenticated-orcid":false,"given":"Jeongwon","family":"Yun","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea"},{"name":"InnoCORE AI\u2010CRED Institute Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6390-7615","authenticated-orcid":false,"given":"Seungju","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1682-3218","authenticated-orcid":false,"given":"Jae Hyuk","family":"Kwon","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34051 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-6200","authenticated-orcid":false,"given":"Luiz Felipe","family":"Vecchietti","sequence":"additional","affiliation":[{"name":"Max Plank Institute for Security and Privacy (MPI\u2010SP)  44799 Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5058-8097","authenticated-orcid":false,"given":"Ji Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Vaccine and Diagnosis Innovation (CEVI) Korea Research Institute of Chemical Technology Daejeon 34114 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0734-8360","authenticated-orcid":false,"given":"Mi\u2010ra","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Vaccine and Diagnosis Innovation (CEVI) Korea Research Institute of Chemical Technology Daejeon 34114 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-0995","authenticated-orcid":false,"given":"Keun Bon","family":"Ku","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Vaccine and Diagnosis Innovation (CEVI) Korea Research Institute of Chemical Technology Daejeon 34114 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-0838","authenticated-orcid":false,"given":"Hyun\u2010Joo","family":"Ro","sequence":"additional","affiliation":[{"name":"Center for Biomolecular and Cellular Structure Institute for Basic Science (IBS) Daejeon 34126 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6872-5583","authenticated-orcid":false,"given":"Kyun\u2010Do","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Infectious Disease Vaccine and Diagnosis Innovation (CEVI) Korea Research Institute of Chemical Technology Daejeon 34114 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4085-9648","authenticated-orcid":false,"given":"Meeyoung","family":"Cha","sequence":"additional","affiliation":[{"name":"Max Plank Institute for Security and Privacy (MPI\u2010SP)  44799 Bochum Germany"},{"name":"School of Computing Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5055-902X","authenticated-orcid":false,"given":"Hyun Jung","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2511-7064","authenticated-orcid":false,"given":"Ji Eun","family":"Oh","sequence":"additional","affiliation":[{"name":"Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34051 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-3643","authenticated-orcid":false,"given":"Ho Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea"},{"name":"InnoCORE AI\u2010CRED Institute Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1303"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90154-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni873"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni875"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33354"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00272-10"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0182-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.025"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107863"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104860"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00840-x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26993"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09544-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3212"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1338096"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30566-X"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209760"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22177-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2023184"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.04.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.05.008"},{"key":"e_1_2_9_23_1","volume":"13","author":"Shin H.","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c13677"},{"key":"e_1_2_9_25_1","first-page":"39","author":"Chong Z. L.","year":"2022","journal-title":"Cell Rep."},{"key":"e_1_2_9_26_1","volume":"9","author":"Beule A. G.","year":"2010","journal-title":"GMS Curr Top Otorhinolaryngol Head Neck Surg"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b14-00398"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14093754"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154833"},{"key":"e_1_2_9_30_1","author":"Syedbasha M.","year":"2016","journal-title":"J Vis Exp"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.87"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1985.tb09091.x"},{"key":"e_1_2_9_34_1","first-page":"145","volume":"916","author":"Wigley D. B.","year":"1987","journal-title":"Bioch. Biophys. Acta"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/344363a0"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-5-9"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21187"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06415-8"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1105"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360221211"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.add2187"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080635"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(87)90038-6"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.6b00819"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.7b00125"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059004"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2389"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.002923"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.017"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20319"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.241"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.10.013"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096967"},{"key":"e_1_2_9_55_1","first-page":"343","volume":"8","author":"Goodson R. J.","year":"1990","journal-title":"Site\u2010Directed Pegylation of Recombinant Interleukin\u20102 at Its Glycosylation Site, Bio\u2010Technol"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC02719B"},{"key":"e_1_2_9_57_1","volume":"16","author":"Santhanakrishnan K. R.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608611104"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.08.010"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1601556"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2019.01.020"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.09.068"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.2.9805117"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2006.20.2935"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-021-05330-0"},{"key":"e_1_2_9_66_1","first-page":"493","volume":"27","author":"Lj R.","year":"1938","journal-title":"Am J Hyg"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016650117"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad275"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2024.101559"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01301"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108435"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0666-6"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50955-0"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2314853121"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10941"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-022-00849-w"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-021-00714-2"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40529-025-00462-2"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.2165\/11530550-000000000-00000"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt799"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1252"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2804"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004782"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000017"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190295"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0345-x"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381270-4.00019-6"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38328-5"},{"key":"e_1_2_9_89_1","author":"Lisanza S. L.","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adu2454"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03828-1"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-0848-2"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac345"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902840116"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202506764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202506764","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202506764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:47:29Z","timestamp":1775980049000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202506764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":94,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/advs.202506764"],"URL":"https:\/\/doi.org\/10.1002\/advs.202506764","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e06764"}}