{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:24:06Z","timestamp":1790011446009,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF\u20102024\u201000347660"],"award-info":[{"award-number":["NRF\u20102024\u201000347660"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute Compartment Syndrome (ACS) is a serious medical condition that arises from increased pressure within osteofascial compartments, leading to impaired blood flow and potential tissue damage. Early and accurate diagnosis is critical for preventing permanent damage. Current methods rely largely on qualitative assessments with limited accuracy, and those that exploit invasive pressure measurements often prove inadequate. Herein, a soft materials\u2010based multimodal sensor probe is introduced, as well as the mechanical and thermal influences to monitor intra\u2010compartmental pressure, tissue oxygen saturation (StO\n                    <jats:sub>2<\/jats:sub>\n                    ), and blood flow simultaneously at a common location within an affected compartment. The system integrates three sensors into a thin, flexible probe capable of real\u2010time, wireless data transmission. The device allows for continuous monitoring with high reproducibility and sensitivity, to enhance diagnostic accuracy relative to current clinical practice, with the potential to early diagnosis of an acute compartment syndrome that requires fasciotomies. Large animal model studies, including short\u2010 and intermediate\u2010term reliability assessments, highlight the key engineering features. The results reveal expected inverse relationships between pressure, StO\n                    <jats:sub>2<\/jats:sub>\n                    , and flow rate under simulated compartment syndrome conditions. This multimodal approach enhances diagnostic precision, offers real\u2010time insights, and promises to yield improved outcomes through a comprehensive, quantitative diagnosis of compartment syndrome.\n                  <\/jats:p>","DOI":"10.1002\/advs.202506942","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T17:40:47Z","timestamp":1752774047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Minimally Invasive, Bioadaptive Multimodal Sensor Probe with Safe Deployment for Real\u2010Time Acute Compartment Syndrome Diagnosis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-2019","authenticated-orcid":false,"given":"Seung Gi","family":"Seo","sequence":"first","affiliation":[{"name":"Center for Bio\u2010Integrated Electronics Northwestern University  Evanston IL 60208 USA"},{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungyeob","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering Korea Advanced Institute of Science &amp; Technology  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonggwang","family":"Yoo","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010Integrated Electronics Northwestern University  Evanston IL 60208 USA"},{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"},{"name":"College of Biomedical Science &amp; Health Inje University  Gimhae 50834 Republic of Korea"},{"name":"Department of Digital Anti\u2010aging Healthcare Graduate School of Inje University  Gimhae 50834 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-1117","authenticated-orcid":false,"given":"Seyong","family":"Oh","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010Integrated Electronics Northwestern University  Evanston IL 60208 USA"},{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"},{"name":"Division of Electrical Engineering Hanyang University ERICA  Ansan 15588 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwen","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering University of California San Diego  La Jolla CA 92093 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengyao","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering Northwestern University  Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bosung","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010Integrated Electronics Northwestern University  Evanston IL 60208 USA"},{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering Northwestern University  Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Lu","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010Integrated Electronics Northwestern University  Evanston IL 60208 USA"},{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"},{"name":"School of Microelectronics University of Science and Technology of China  Hefei Anhui 230026 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Bin","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Information Display Kyung Hee University  Seoul 02447 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Westman","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery Washington University School of Medicine  St. Louis MO 63110 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Moritz","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery Washington University School of Medicine  St. Louis MO 63110 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Ribaudo","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery Washington University School of Medicine  St. Louis MO 63110 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010Integrated Electronics Northwestern University  Evanston IL 60208 USA"},{"name":"Querrey Simpson Institute for Bioelectronics Northwestern University  Evanston IL 60208 USA"},{"name":"Department of Mechanical Engineering Northwestern University  Evanston IL 60208 USA"},{"name":"Department of Materials Science and Engineering Northwestern University  Evanston IL 60208 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell A.","family":"Pet","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery Department of Surgery Washington University School of Medicine  St. Louis MO 63110 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