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To overcome this issue, a pump\u2010free, hydraulic\u2010amplification oscillatory microfluidic (PHOMF) device is presented, which can be actuated by fingers to handle particles and cells within the microchannel. The PHOMF device has a hydraulic\u2010amplification module for pressure transfer and a soft microchannel module for the generation of oscillatory flows. This is made possible by the periodic transfer of finger\u2010driven liquid pressure to the soft microchannel. This pressure causes the soft microchannel to deform and then drives the reciprocating flow of fluid volumes within the microchannel. In the oscillatory flow, particles and cells achieve single\u2010line focusing driven by the spatially accumulated inertial and elastic lift forces. The particle elasto\u2010inertial focusing theory in the PHOMF microchannel has been revealed. To demonstrate the system's practicality, the PHOMF device is utilized to achieve the early observation of platelet clots (3\u00a0min) and the rapid staining of cancer cells (8\u00a0min). The PHOMF device provides a miniaturized, inexpensive, and efficient detection tool for lab\u2010on\u2010a\u2010chip, and has the potential to become a mass\u2010produced, widely available, and convenient disease detection product.<\/jats:p>","DOI":"10.1002\/advs.202507041","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T08:10:42Z","timestamp":1747987842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Pump\u2010Free, Hydraulic\u2010Amplification Oscillatory Microfluidic Device for Continuous Particle and Cell Manipulation"],"prefix":"10.1002","volume":"12","author":[{"given":"Yong","family":"Liu","sequence":"first","affiliation":[{"name":"Institute for Advanced Study Shenzhen University Shenzhen 518060 China"},{"name":"College of Mechatronics and Control Engineering Shenzhen University Shenzhen 518060 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