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Importantly, CRISPR\/Cas9\u2010mediated\n                    <jats:italic>Piezo1<\/jats:italic>\n                    gene editing significantly reduces graft survival in vivo when transplanted with 16% hydrogel, confirming that Piezo1\u2010mediated mechanotransduction is essential for stiffness\u2010dependent NSC survival. These findings reveal a previously unrecognized mechanism governing graft survival and suggest that optimizing mechanical properties of biomaterial scaffolds or directly targeting Piezo1\u2010dependent mechanotransduction could substantially improve outcomes of cell\u2010based therapies for neurological disorders.\n                  <\/jats:p>","DOI":"10.1002\/advs.202507160","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:32:42Z","timestamp":1762162362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1\u2010Mediated Mechanotransduction"],"prefix":"10.1002","volume":"13","author":[{"given":"Hee Hwan","family":"Park","sequence":"first","affiliation":[{"name":"Department of Brain Science Ajou University School of 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