{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:00:35Z","timestamp":1785441635630,"version":"3.56.0"},"reference-count":57,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92259205"],"award-info":[{"award-number":["92259205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402494"],"award-info":[{"award-number":["82402494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["824B2061"],"award-info":[{"award-number":["824B2061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["24YF2735500"],"award-info":[{"award-number":["24YF2735500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2023ZZ02025"],"award-info":[{"award-number":["2023ZZ02025"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Post\u2010transplanted dysfunction remains the key unsolved challenge to construct bioengineered complex organs. Herein, by analyzing the bioengineered trachea, it is found that multiple tissue senescences occur, and poor endogenous cellular contact and exogenous immune microenvironment dysregulation are identified as two crucial factors during senescence. Therefore, a Hebe engineered trachea (Hebe\u2010ET) with a ring\u2013ring structure and dual anti\u2010senescence designs is proposed for maintaining regenerative homeostasis after transplantation. First, in the cartilage rings, a fiber\u2010film structural scaffold is designed to promote close\u2010packed cellular contact, significantly reducing senescent P21+ chondrocytes. Furthermore, between the cartilage rings are distributed fibrous connective tissue rings, in which the loaded quercetin induces an immune cascade to restrain senescence in multiple cells, including chondrocytes, endothelial cells, and fibroblasts via mitochondrion\u2010targeted oxidative stress scavenging, promoting the development of the full tracheal components in vivo. Based on these designs, 12 weeks after orthotopic transplantation, the Hebe\u2010ET achieves sustainable youth and develops a natural\u2010like structure with mature cartilage phenotype, reconstructed vascular network, and epithelium coverage. The mechanical property exceeds that of the natural trachea, and 87.5% of animals survived. This study first reveals the necessity of anti\u2010senescence design in the fabrication of complex organ substitutes and proposes an effective engineering strategy for segmental trachea reconstruction.<\/jats:p>","DOI":"10.1002\/advs.202507186","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:33Z","timestamp":1751846433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Engineered Anti\u2010Senescence Trachea With Post\u2010Transplanted Regenerative Homeostasis"],"prefix":"10.1002","volume":"12","author":[{"given":"Ziyin","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 200433 China"},{"name":"Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 200433 China"},{"name":"Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Fashion Henan Institute of Science and Technology  Xinxiang 453003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 200433 China"},{"name":"Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 200433 China"},{"name":"Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runfeng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 200433 China"},{"name":"Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Surgery, Fujian Cancer Hospital Clinical Oncology School of Fujian Medical University  Fuzhou 350014 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 200433 China"},{"name":"Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 200433 China"},{"name":"Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Ningbo No.2 Hospital  Ningbo 315010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Ningbo No.2 Hospital  Ningbo 315010 China"},{"name":"Ningbo Institute of Life and Health Industry University of Chinese Academy of Sciences  Ningbo 315016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 200433 China"},{"name":"Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Laboratory and Department of Medical Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine University of Electronic Science and Technology of China  Sichuan 610072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Li","sequence":"additional","affiliation":[{"name":"Nonwoven Technology Laboratory College of Textile Science and Engineering Jiangnan University  Wuxi 214122 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-3110","authenticated-orcid":false,"given":"Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai 200433 China"},{"name":"Shanghai Engineering Research Center of Lung Transplantation, Shanghai Pulmonary Hospital Tongji University  Shanghai 200433 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,6]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.05.059"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00510-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51746-3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211602"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16350"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.09.027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231151826"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)40036-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405255"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2023.03.027"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00583-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-023-00281-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001244"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310876"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158134"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.09.012"},{"key":"e_1_2_9_17_1","volume":"7","author":"Han M. K.","year":"2020","journal-title":"BMJ Open Respir. Res."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104481"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.2084"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01046-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05535-x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abo4272"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112145"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01478-6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103059"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102446"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10525"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11030243"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10671"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0154-2021"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202004276"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.09.011"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202212830"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.155138"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.43028"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300873"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100848"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.03.013"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116107"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.01.010"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201704757"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00105"},{"key":"e_1_2_9_43_1","first-page":"1300","volume":"384","author":"Magalh\u00e3es J. P.","year":"2024","journal-title":"Sci. Amer. Assoc. Adv. Sci."},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01502-8"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01348-2"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101995"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301493"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg3365"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202270199"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101839"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11020198"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.10.034"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1567657"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-017-4138-8"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1452780"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004509"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.16-0443"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202507186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.202507186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.202507186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:11:31Z","timestamp":1785438691000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202507186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,6]]},"references-count":57,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/advs.202507186"],"URL":"https:\/\/doi.org\/10.1002\/advs.202507186","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,6]]},"assertion":[{"value":"2025-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e07186"}}